4I24
Structure of T790M EGFR kinase domain co-crystallized with dacomitinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 329 | 37478.4 | 2 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
| 2 | C, D (A, B) | (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | non-polymer | 469.9 | 2 | Chemie (1C9) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A, B: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 694 | - | EXPRESSION TAG |
| Met 790 | Thr 790 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74956.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 939.9 | |
| All* | Total formula weight | 75896.6 |
