4LKL

Crystal structure of Plk1 Polo-box domain in complex with PL-55

Summary for 4LKL

• Entry DOI: 10.2210/pdb4lkl/pdb
• Related: 4LKM
• Related PRD ID: PRD_001156
• Descriptor: Serine/threonine-protein kinase PLK1, PL-55, ADAMANTANE, ... (4 entities in total)
• Functional Keywords: polo-box domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P53350
• Total number of polymer chains: 2
• Total formula weight: 26624.45

Authors

Lee, W.C.,Song, J.H.,Kim, H.Y. (deposition date: 2013-07-08, release date: 2013-12-11, Last modification date: 2023-11-08)

• Primary citation: Murugan, R.N.,Ahn, M.,Lee, W.C.,Kim, H.Y.,Song, J.H.,Cheong, C.,Hwang, E.,Seo, J.H.,Shin, S.Y.,Choi, S.H.,Park, J.E.,Bang, J.K.; Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1; Plos One, 8:e80043-e80043, 2013; PubMed: 24223211; DOI: 10.1371/journal.pone.0080043

Experimental method

X-RAY DIFFRACTION (1.58 Å)