4LKL
Crystal structure of Plk1 Polo-box domain in complex with PL-55
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ADM B 101 |
| Chain | Residue |
| A | ARG518 |
| B | ACE2 |
| B | PRO3 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR CHAIN B OF PL-55 |
| Chain | Residue |
| A | PHE535 |
| A | HIS538 |
| A | LYS540 |
| A | HOH606 |
| B | ADM101 |
| B | HOH201 |
| B | HOH202 |
| B | HOH203 |
| B | HOH204 |
| B | HOH205 |
| B | HOH206 |
| B | HOH207 |
| B | HOH208 |
| B | HOH210 |
| B | HOH211 |
| B | HOH214 |
| A | LYS413 |
| A | TRP414 |
| A | ASP416 |
| A | LEU490 |
| A | LEU491 |
| A | ARG516 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Domain: {"description":"POLO box 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 82 |
| Details | Domain: {"description":"POLO box 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Region: {"description":"Important for interaction with phosphorylated proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23455478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
