3BPL
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![BU of 3bpl by Molmil](/molmil-images/mine/3bpl) | Crystal structure of the IL4-IL4R-Common Gamma ternary complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Garcia, K.C. | 登録日 | 2007-12-18 | 公開日 | 2008-02-05 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System. Cell(Cambridge,Mass.), 132, 2008
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7CVN
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![BU of 7cvn by Molmil](/molmil-images/mine/7cvn) | The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 4-(3-acetamidophenyl)-N-(4-methoxyphenyl)sulfonyl-7-nitro-1H-indole-2-carboxamide, Fructose-1,6-bisphosphatase 1 | 著者 | Wang, X, Zhou, J, Xu, B. | 登録日 | 2020-08-26 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Design,synthesis,biological evaluation and binding mode analysis of 7-nitro-indole-N-acylarylsulfonamide-based fructose-1,6-bisphosphatase inhibitors Chinese journal of medicinal chemistry, 30, 2020
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3L6P
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![BU of 3l6p by Molmil](/molmil-images/mine/3l6p) | Crystal Structure of Dengue Virus 1 NS2B/NS3 protease | 分子名称: | CADMIUM ION, NICKEL (II) ION, SULFATE ION, ... | 著者 | Chandramouli, S, Joseph, J.S, Daudenarde, S, Gatchalian, J, Cornillez-Ty, C, Kuhn, P. | 登録日 | 2009-12-23 | 公開日 | 2010-03-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family. J.Virol., 84, 2010
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3PHE
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![BU of 3phe by Molmil](/molmil-images/mine/3phe) | HCV NS5B with a bound quinolone inhibitor | 分子名称: | 4-chlorobenzyl 6-fluoro-7-(4-methylpiperazin-1-yl)-1-[4-(methylsulfonyl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxylate, HCV encoded nonstructural 5B protein | 著者 | Somoza, J.R, To, N, Lehoux, I. | 登録日 | 2010-11-03 | 公開日 | 2010-11-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Quinolones as HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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8UO1
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![BU of 8uo1 by Molmil](/molmil-images/mine/8uo1) | CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class Q) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-10-19 | 公開日 | 2024-03-06 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
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1E9N
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![BU of 1e9n by Molmil](/molmil-images/mine/1e9n) | A second divalent metal ion in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1, and its implications for the catalytic mechanism | 分子名称: | DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE, LEAD (II) ION | 著者 | Beernink, P.T, Segelke, B.W, Rupp, B. | 登録日 | 2000-10-24 | 公開日 | 2001-02-16 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Two Divalent Metal Ions in the Active Site of a New Crystal Form of Human Apurinic/Apyrimidinic Endonuclease, Ape1: Implications for the Catalytic Mechanism J.Mol.Biol., 307, 2001
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6LBE
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4M5U
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![BU of 4m5u by Molmil](/molmil-images/mine/4m5u) | 5-(4-FLUOROPHENYL)-3-HYDROXY-6-[4-(1H-1,2,3,4-TETRAZOL-5-YL)PHENYL]-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 pH1N1 endonuclease | 分子名称: | 5-(4-fluorophenyl)-3-hydroxy-6-[4-(1H-tetrazol-5-yl)phenyl]pyridin-2(1H)-one, MANGANESE (II) ION, Polymerase PA, ... | 著者 | Bauman, J.D, Patel, D, Das, K, Arnold, E. | 登録日 | 2013-08-08 | 公開日 | 2013-09-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Phenyl substituted 3-hydroxypyridin-2(1H)-ones: inhibitors of influenza A endonuclease. Bioorg.Med.Chem., 21, 2013
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5C2K
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![BU of 5c2k by Molmil](/molmil-images/mine/5c2k) | Crystal structure of the fusion protein linked by RhoA and the GAP domain of MgcRacGAP | 分子名称: | ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Murayama, K, Kato-Murayama, M, Hosaka, T, Kitamura, T, Yokoyama, S, Shirouzu, M. | 登録日 | 2015-06-16 | 公開日 | 2016-06-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Structural basis of G-protein target alternation of MgcRacGAP by phospholylation To Be Published
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1BIX
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![BU of 1bix by Molmil](/molmil-images/mine/1bix) | THE CRYSTAL STRUCTURE OF THE HUMAN DNA REPAIR ENDONUCLEASE HAP1 SUGGESTS THE RECOGNITION OF EXTRA-HELICAL DEOXYRIBOSE AT DNA ABASIC SITES | 分子名称: | AP ENDONUCLEASE 1, PLATINUM (II) ION, SAMARIUM (III) ION | 著者 | Gorman, M.A, Morera, S, Rothwell, D.G, De La Fortelle, E, Mol, C.D, Tainer, J.A, Hickson, I.D, Freemont, P.S. | 登録日 | 1998-06-19 | 公開日 | 1999-06-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites. EMBO J., 16, 1997
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3QAZ
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![BU of 3qaz by Molmil](/molmil-images/mine/3qaz) | IL-2 mutant D10 ternary complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-2, ... | 著者 | Levin, A.M, Bates, D.L, Ring, A.M, Lin, J.T, Su, L, Krieg, C, Bowman, G.R, Novick, P, Pande, V.S, Khort, H.E, Boyman, O, Gathman, C.G, Garcia, K.C. | 登録日 | 2011-01-12 | 公開日 | 2012-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.802 Å) | 主引用文献 | Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature, 484, 2012
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1DL6
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![BU of 1dl6 by Molmil](/molmil-images/mine/1dl6) | SOLUTION STRUCTURE OF HUMAN TFIIB N-TERMINAL DOMAIN | 分子名称: | TRANSCRIPTION FACTOR II B (TFIIB), ZINC ION | 著者 | Chen, H.-T, Legault, P, Glushka, J, Omichinski, J.G, Scott, R.A. | 登録日 | 1999-12-08 | 公開日 | 2000-10-18 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of a (Cys3His) zinc ribbon, a ubiquitous motif in archaeal and eucaryal transcription. Protein Sci., 9, 2000
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6G40
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![BU of 6g40 by Molmil](/molmil-images/mine/6g40) | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH9525 | 分子名称: | ACETATE ION, DI(HYDROXYETHYL)ETHER, N-glycosylase/DNA lyase, ... | 著者 | Masuyer, G, Helleday, T, Stenmark, P. | 登録日 | 2018-03-26 | 公開日 | 2019-04-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1. Chemmedchem, 18, 2023
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4I80
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6G3X
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6G3Y
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![BU of 6g3y by Molmil](/molmil-images/mine/6g3y) | Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH5675 | 分子名称: | 4-(4-azanyl-2-oxidanylidene-3~{H}-benzimidazol-1-yl)-~{N}-(4-iodophenyl)piperidine-1-carboxamide, ACETATE ION, N-glycosylase/DNA lyase, ... | 著者 | Masuyer, G, Helleday, T, Stenmark, P. | 登録日 | 2018-03-26 | 公開日 | 2018-11-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science, 362, 2018
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1RR7
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8BJH
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![BU of 8bjh by Molmil](/molmil-images/mine/8bjh) | chimera of the inactive ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, with the double mutation K3528M and K3535I, fused to a proline-Rich-Domain (PRD) and profilin, bound to Latrunculin B-ADP-Mg-actin | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | 著者 | Teixeira-Nunes, M, Renault, L, Retailleau, P. | 登録日 | 2022-11-04 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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8BJI
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![BU of 8bji by Molmil](/molmil-images/mine/8bji) | chimera of ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo fused to a proline-Rich-Domain (PRD) and profilin, bound to ADP-Mg-actin and a sulfate ion | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | 著者 | Teixeira-Nunes, M, Renault, L, Retailleau, P. | 登録日 | 2022-11-04 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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8BJJ
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![BU of 8bjj by Molmil](/molmil-images/mine/8bjj) | ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | 著者 | Teixeira-Nunes, M, Renault, L, Retailleau, P. | 登録日 | 2022-11-04 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | 主引用文献 | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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8VGZ
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4NH1
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![BU of 4nh1 by Molmil](/molmil-images/mine/4nh1) | Crystal structure of a heterotetrameric CK2 holoenzyme complex carrying the Andante-mutation in CK2beta and consistent with proposed models of autoinhibition and trans-autophosphorylation | 分子名称: | Casein kinase II subunit alpha, Casein kinase II subunit beta, GLYCEROL, ... | 著者 | Schnitzler, A, Issinger, O.-G, Niefind, K. | 登録日 | 2013-11-04 | 公開日 | 2014-03-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | The Protein Kinase CK2(Andante) Holoenzyme Structure Supports Proposed Models of Autoregulation and Trans-Autophosphorylation J.Mol.Biol., 426, 2014
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7AYZ
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7AZ0
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7KAF
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![BU of 7kaf by Molmil](/molmil-images/mine/7kaf) | The crystal structure of the 2009/H1N1/California PA endonuclease I38T (construct with truncated loop 51-72) in complex with baloxavir acid | 分子名称: | Baloxavir acid, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... | 著者 | Cuypers, M.G, Kumar, G, Slavish, J, White, S.W. | 登録日 | 2020-09-30 | 公開日 | 2021-02-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism. Nucleic Acids Res., 49, 2021
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