4M5U

5-(4-FLUOROPHENYL)-3-HYDROXY-6-[4-(1H-1,2,3,4-TETRAZOL-5-YL)PHENYL]-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 pH1N1 endonuclease

Summary for 4M5U

• Entry DOI: 10.2210/pdb4m5u/pdb
• Related: 4KIL 4LN7 4M5O 4M5Q 4M5R 4M5V
• Descriptor: Polymerase PA, MANGANESE (II) ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: cap-snatching, rna binding protein-inhibitor, rna binding protein-inhibitor complex, rna binding protein/inhibitor
• Biological source: Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1))
• Total number of polymer chains: 1
• Total formula weight: 29115.47

Authors

Bauman, J.D.,Patel, D.,Das, K.,Arnold, E. (deposition date: 2013-08-08, release date: 2013-09-25, Last modification date: 2024-02-28)

• Primary citation: Parhi, A.K.,Xiang, A.,Bauman, J.D.,Patel, D.,Vijayan, R.S.,Das, K.,Arnold, E.,Lavoie, E.J.; Phenyl substituted 3-hydroxypyridin-2(1H)-ones: inhibitors of influenza A endonuclease.; Bioorg.Med.Chem., 21:6435-6446, 2013; PubMed: 24055080; DOI: 10.1016/j.bmc.2013.08.053

Experimental method

X-RAY DIFFRACTION (2.2 Å)