PDB: 5470 件ウェブページステータス検索Chemie searchBIRD

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2BQZ	Crystal structure of a ternary complex of the human histone methyltransferase Pr-SET7 (also known as SET8) 分子名称: HISTONE H4, S-ADENOSYL-L-HOMOCYSTEINE, SET8 PROTEIN 著者 Xiao, B, Jing, C, Kelly, G, Walker, P.A, Muskett, F.W, Frenkiel, T.A, Martin, S.R, Sarma, K, Reinberg, D, Gamblin, S.J, Wilson, J.R. 登録日 2005-04-28 公開日 2005-06-08 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Specificity and Mechanism of the Histone Methyltransferase Pr-Set7 Genes Dev., 19, 2005
5UMS	Crystal structure of middle double PH domain of human FACT complex subunit SSRP1 分子名称: FACT complex subunit SSRP1 著者 Su, D, Hu, Q, Thompson, J.R, Botuyan, M.V, Mer, G. 登録日 2017-01-29 公開日 2018-01-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.569 Å) 主引用文献 Crystal structure of middle double PH domain of human FACT complex subunit SSRP1 To Be Published
2C6E	Aurora A kinase activated mutant (T287D) in complex with a 5- aminopyrimidinyl quinazoline inhibitor 分子名称: N-{5-[(7-{[(2S)-2-HYDROXY-3-PIPERIDIN-1-YLPROPYL]OXY}-6-METHOXYQUINAZOLIN-4-YL)AMINO]PYRIMIDIN-2-YL}BENZAMIDE, SERINE/THREONINE-PROTEIN KINASE 6 著者 Pauptit, R.A, Pannifer, A.D, Breed, J, McMiken, H.H.J, Rowsell, S, Anderson, M. 登録日 2005-11-09 公開日 2006-01-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Sar and Inhibitor Complex Structure Determination of a Novel Class of Potent and Specific Aurora Kinase Inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
5UWI	Crystal Structure of HDAC5 NES Peptide in complex with CRM1-Ran-RanBP1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.143 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5UWW	Crystal Structure of DEAF1 Peptide in complex with CRM1 K579A mutant-Ran-RanBP1 分子名称: Deformed epidermal autoregulatory factor 1 homolog, Exportin-1, GLYCEROL, ... 著者 Fung, H.Y.J, Chook, Y.M. 登録日 2017-02-21 公開日 2017-03-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.152 Å) 主引用文献 Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5V9P	Crystal structure of pyrrolidine amide inhibitor [(3S)-3-(4-bromo-1H-pyrazol-1-yl)pyrrolidin-1-yl][3-(propan-2-yl)-1H-pyrazol-5-yl]methanone (compound 35) in complex with KDM5A 分子名称: Lysine-specific demethylase 5A, NICKEL (II) ION, SULFATE ION, ... 著者 Kiefer, J.R, Liang, J, Vinogradova, M. 登録日 2017-03-23 公開日 2017-05-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
5UKF	Crystal Structure of the Human Vaccinia-related Kinase 1 Bound to an Oxindole Inhibitor 分子名称: 4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}benzene-1-sulfonamide, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Counago, R.M, Wells, C, Zuercher, W, Willson, T.M, Bountra, C, Edwards, A.M, Arruda, P, Gileadi, O, Structural Genomics Consortium (SGC) 登録日 2017-01-22 公開日 2017-03-29 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep, 7, 2017
2HGM	NMR structure of the second qRRM domain of human hnRNP F 分子名称: Heterogeneous nuclear ribonucleoprotein F 著者 Dominguez, C, Allain, F.H.-T. 登録日 2006-06-27 公開日 2006-07-11 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition. Nucleic Acids Res., 34, 2006
5VBO	CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH LRRK2-IN-1 分子名称: 1,2-ETHANEDIOL, 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4, ... 著者 ZHU, J.-Y, SCHONBRUNN, E. 登録日 2017-03-30 公開日 2018-04-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 2021
2C62	Crystal Structure of the Human Transcription Cofactor PC4 in Complex with Single-Stranded DNA 分子名称: 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP *TP*TP*TP*TP*TP*TP*TP*TP*TP*G)-3', ACTIVATED RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR P15, SULFATE ION 著者 Werten, S, Moras, D. 登録日 2005-11-07 公開日 2006-01-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 A Global Transcription Cofactor Bound to Juxtaposed Strands of Unwound DNA Nat.Struct.Mol.Biol., 13, 2006
2C6D	Aurora A kinase activated mutant (T287D) in complex with ADPNP 分子名称: GLYCEROL, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Pauptit, R.A, Pannifer, A.D, Breed, J, McMiken, H.H.J, Rowsell, S, Anderson, M. 登録日 2005-11-09 公開日 2006-01-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Sar and Inhibitor Complex Structure Determination of a Novel Class of Potent and Specific Aurora Kinase Inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
2D8Z	Solution structure of the third LIM domain of Four and a half LIM domains protein 2 (FHL-2) 分子名称: Four and a half LIM domains 2, ZINC ION 著者 Qin, X.R, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-08 公開日 2006-06-08 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the third LIM domain of Four and a half LIM domains protein 2 (FHL-2) To be published
5VZS	BRD4-BD1 in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide) 分子名称: 1,2-ETHANEDIOL, 3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-N-methyl-1-(oxan-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide, Bromodomain-containing protein 4 著者 Murray, J.M. 登録日 2017-05-29 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.707 Å) 主引用文献 GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of CBP/P300 To be published
2FBT	WRN exonuclease 分子名称: ACETIC ACID, Werner syndrome helicase 著者 Perry, J.J. 登録日 2005-12-10 公開日 2006-04-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat.Struct.Mol.Biol., 13, 2006
5VY5	Rabbit muscle aldolase using 200keV 分子名称: Fructose-bisphosphate aldolase A 著者 Herzik Jr, M.A, Wu, M, Lander, G.C. 登録日 2017-05-24 公開日 2017-06-14 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Achieving better-than-3- angstrom resolution by single-particle cryo-EM at 200 keV. Nat. Methods, 14, 2017
2D99	Solution Structure of RSGI RUH-048, a GTF2I domain in human cDNA 分子名称: General transcription factor II-I repeat domain-containing protein 1 著者 Doi-Katayama, Y, Hirota, H, Tochio, N, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-09 公開日 2006-06-09 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution Structure of RSGI RUH-048, a GTF2I domain in human cDNA To be Published
2D9P	Solution structure of RNA binding domain 4 in Polyadenylation binding protein 3 分子名称: Polyadenylate-binding protein 3 著者 Tsuda, K, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-12-12 公開日 2006-06-12 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of RNA binding domain 4 in Polyadenylation binding protein 3 To be Published
2G9A	Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 分子名称: Histone H3, WD-repeat protein 5 著者 Chai, J, Han, Z, Wang, H, Shen, Y. 登録日 2006-03-06 公開日 2006-09-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 To be published
2GGM	Human centrin 2 xeroderma pigmentosum group C protein complex 分子名称: CALCIUM ION, Centrin-2, DNA-repair protein complementing XP-C cells 著者 Thompson, J.R. 登録日 2006-03-24 公開日 2006-04-25 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 The structure of the human centrin 2-xeroderma pigmentosum group C protein complex. J.Biol.Chem., 281, 2006
2BR9	14-3-3 Protein Epsilon (Human) Complexed to Peptide 分子名称: 14-3-3 PROTEIN EPSILON, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS 著者 Yang, X, Elkins, J.M, Soundararajan, M, Fedorov, O, Sundstrom, M, Edwards, A, Arrowsmith, C, Doyle, D.A. 登録日 2005-05-03 公開日 2005-05-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
2BQ0	14-3-3 Protein Beta (Human) 分子名称: 14-3-3 BETA/ALPHA 著者 Yang, X, Elkins, J.M, Fedorov, O, Longman, E.J, Sobott, L, Ball, L.J, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A. 登録日 2005-04-26 公開日 2005-05-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
5VOM	Benzopiperazine BET bromodomain inhibitor in complex with BD1 of Brd4 分子名称: 3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl]-N-methylbenzamide, Bromodomain-containing protein 4 著者 Toms, A.V, Herbertz, T. 登録日 2017-05-03 公開日 2017-08-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains. ACS Med Chem Lett, 8, 2017
2G76	Crystal structure of human 3-phosphoglycerate dehydrogenase 分子名称: D-3-phosphoglycerate dehydrogenase, D-MALATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Turnbull, A.P, Salah, E, Savitsky, P, Gileadi, O, von Delft, F, Edwards, A, Arrowsmith, C, Weigelt, J, Sundstrom, M, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2006-02-27 公開日 2006-03-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human 3-phosphoglycerate dehydrogenase To be Published
5W55	Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048 分子名称: 1,2-ETHANEDIOL, 11-ethyl-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Bromodomain-containing protein 4 著者 Xu, X, Blacklow, S.C. 登録日 2017-06-14 公開日 2018-06-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.354 Å) 主引用文献 Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048 To Be Published
2FMM	Crystal Structure of EMSY-HP1 complex 分子名称: Chromobox protein homolog 1, Protein EMSY, SULFATE ION 著者 Huang, Y. 登録日 2006-01-09 公開日 2006-05-23 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding. Structure, 14, 2006

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