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5W55

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048

Summary for 5W55
Entry DOI10.2210/pdb5w55/pdb
DescriptorBromodomain-containing protein 4, 11-ethyl-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordskinase, inhibitor, cell cycle
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight15716.07
Authors
Xu, X.,Blacklow, S.C. (deposition date: 2017-06-14, release date: 2018-06-20, Last modification date: 2023-10-04)
Primary citationXu, X.,Blacklow, S.C.
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.354 Å)
Structure validation

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