PDB: 615 件ウェブページステータス検索Chemie searchBIRD

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3K74	Disruption of protein dynamics by an allosteric effector antibody 分子名称: Dihydrofolate reductase, Nanobody 著者 Oyen, D, Srinivasan, V, Steyaert, J, Barlow, J. 登録日 2009-10-12 公開日 2010-10-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition. J.Mol.Biol., 407, 2011
3L3R	Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis jirovecii, Pneumocystis carinii and Human Dihydrofolate Reductase and Their Active Site Mutants 分子名称: 6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Cody, V. 登録日 2009-12-17 公開日 2011-01-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants. Antimicrob.Agents Chemother., 57, 2013
3N0H	hDHFR double mutant Q35S/N64F Trimethoprim Binary Complex 分子名称: Dihydrofolate reductase, SULFATE ION, TRIMETHOPRIM 著者 Cody, V. 登録日 2010-05-14 公開日 2011-09-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. J.Struct.Biol., 176, 2011
3M08	Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1 分子名称: 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine, Dihydrofolate reductase, GLYCEROL, ... 著者 Bourne, C.R, Barrow, W.W. 登録日 2010-03-02 公開日 2010-07-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.014 Å) 主引用文献 Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1. Antimicrob.Agents Chemother., 54, 2010
3M09	F98Y TMP-resistant Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1 分子名称: 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine, Dihydrofolate reductase, GLYCEROL, ... 著者 Bourne, C.R, Barrow, W.W. 登録日 2010-03-02 公開日 2010-07-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.009 Å) 主引用文献 Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1. Antimicrob.Agents Chemother., 54, 2010
3S9U	Bacillus anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP120J 分子名称: 6-ethyl-5-[3-(4-methoxybiphenyl-3-yl)prop-1-yn-1-yl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Anderson, A.C, Beierlein, J.M. 登録日 2011-06-02 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-Activity Studies of Heterocyclic Propargyl-linked TMP Analogs Targeting Bacillus anthracis Dihydrofolate Reductase To be Published
3SRU	S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines 分子名称: Dihydrofolate reductase, N-[3'-(2,4-diaminoquinazolin-7-yl)-4'-ethoxybiphenyl-3-yl]methanesulfonamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hilgers, M. 登録日 2011-07-07 公開日 2011-08-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg.Med.Chem.Lett., 21, 2011
3S7A	Human dihydrofolate reductase binary complex with PT684 分子名称: 4-({5-[(2,4-diaminopteridin-6-yl)methyl]-5H-dibenzo[b,f]azepin-2-yl}oxy)butanoic acid, Dihydrofolate reductase, SULFATE ION 著者 Cody, V, Pace, J, Nowak, J. 登録日 2011-05-26 公開日 2011-10-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode. Acta Crystallogr.,Sect.D, 67, 2011
3SAI	Bacuills anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP1015 分子名称: 6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, DI(HYDROXYETHYL)ETHER, Dihydrofolate reductase, ... 著者 Anderson, A.C, Beierlein, J.M. 登録日 2011-06-02 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 SAR studies of heterocyclic propargyl-linked TMP analogs targeting Bacillus dihydrofolate reductase To be Published
3SRS	S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines 分子名称: 7-(5-bromo-2-ethoxyphenyl)-6-methylquinazoline-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hilgers, M. 登録日 2011-07-07 公開日 2011-08-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg.Med.Chem.Lett., 21, 2011
3SA2	Bacuills anthracis Dihydrofolate Reductase bound propargyl-linked TMP analog, UCP1014 分子名称: 6-ethyl-5-[3-(5-methoxybiphenyl-3-yl)prop-1-yn-1-yl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Anderson, A.C, Beierlein, J.M. 登録日 2011-06-02 公開日 2012-06-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 SAR studies of heterocyclic propargyl-linked TMP analogs to Bacillus dihydrofolate reductase to be published
3SGY	Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006) 分子名称: 6-ethyl-5-{(3S)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Frey, K.M, Anderson, A.C. 登録日 2011-06-15 公開日 2012-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.598 Å) 主引用文献 Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes. Plos One, 7, 2012
3SH2	Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)pyrimidine-2,4-diamine (UCP120J) 分子名称: 6-ethyl-5-[3-(4-methoxybiphenyl-3-yl)prop-1-yn-1-yl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Frey, K.M, Anderson, A.C. 登録日 2011-06-15 公開日 2012-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.999 Å) 主引用文献 Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes. Plos One, 7, 2012
3SA1	Bacuills anthracis Dihydrofolate Reductase bound propargyl-linked TMP analog, UCP1021 分子名称: 6-ethyl-5-{3-[2-methoxy-5-(pyridin-4-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Anderson, A.C, Beierlein, J.M. 登録日 2011-06-02 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 SAR studies of heterocyclic propargyl-linked TMP analogs to Bacillus dihydrofolate reductase to be published
3S3V	human dihydrofolate reductase Q35K/N64F double mutant binary complex with trimethoprim 分子名称: Dihydrofolate reductase, SULFATE ION, TRIMETHOPRIM 著者 Cody, V, Pace, J, Piraino, J, Queener, S.F. 登録日 2011-05-18 公開日 2011-09-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. J.Struct.Biol., 176, 2011
3SRR	S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines 分子名称: 3-(2,4-diamino-6-methylquinazolin-7-yl)-4-ethoxybenzaldehyde, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hilgers, M. 登録日 2011-07-07 公開日 2011-08-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg.Med.Chem.Lett., 21, 2011
3SQY	S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines 分子名称: 7-(2-methoxyphenyl)quinazoline-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hilgers, M. 登録日 2011-07-06 公開日 2011-08-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg.Med.Chem.Lett., 21, 2011
3SR5	S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines 分子名称: 7-(3,4-dimethoxyphenyl)-6-methylquinazoline-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hilgers, M. 登録日 2011-07-06 公開日 2011-08-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg.Med.Chem.Lett., 21, 2011
3SRW	S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines 分子名称: 7-(2-ethoxynaphthalen-1-yl)-6-methylquinazoline-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hilgers, M. 登録日 2011-07-07 公開日 2011-08-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg.Med.Chem.Lett., 21, 2011
3TQB	Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with folate 分子名称: Dihydrofolate reductase, FOLIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Franklin, M.C, Cassidy, M, Hillerich, B, Love, J. 登録日 2011-09-09 公開日 2011-11-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
3TQA	Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with NADPH 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Franklin, M.C, Cassidy, M, Hillerich, B, Love, J. 登録日 2011-09-09 公開日 2011-11-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
3VCO	Schistosoma mansoni Dihydrofolate reductase 分子名称: Dihydrofolate reductase, SULFATE ION 著者 Serrao, V.H.B, Romanello, L, Cassago, A, DeMarco, R, Pereira, H.M. 登録日 2012-01-04 公開日 2013-03-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.946 Å) 主引用文献 Structure and kinetics assays of recombinant Schistosoma mansoni dihydrofolate reductase. Acta Trop., 170, 2017
3SRQ	S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines 分子名称: 1-[3-(2,4-diamino-6-methylquinazolin-7-yl)phenyl]ethanone, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Hilgers, M. 登録日 2011-07-07 公開日 2011-08-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. Bioorg.Med.Chem.Lett., 21, 2011
3TQ9	Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with methotrexate 分子名称: Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Franklin, M.C, Cassidy, M, Hillerich, B, Love, J. 登録日 2011-09-09 公開日 2011-11-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
3TD8	Structural Analysis of Pneumocystis carinii Dihydrofolate Reductase Complex with NADPH and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1-pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine 分子名称: 6-{2-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenyl}hex-5-ynoic acid, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Cody, V, Pace, J, Stewart, E. 登録日 2011-08-10 公開日 2012-04-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural analysis of Pneumocystis cariniidihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine. Acta Crystallogr.,Sect.F, 68, 2012

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