3M08

Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1

Summary for 3M08

Entry DOI	10.2210/pdb3m08/pdb
Related	3M09
Descriptor	Dihydrofolate reductase, 5-(3,4-dimethoxy-5-{(1E)-3-oxo-3-[(1S)-1-propylphthalazin-2(1H)-yl]prop-1-en-1-yl}benzyl)pyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	folate, dhfr, antimicrobial, antibiotic resistance, nadp, one-carbon metabolism, oxidoreductase', oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	19762.14
Authors	Bourne, C.R.,Barrow, W.W. (deposition date: 2010-03-02, release date: 2010-07-14, Last modification date: 2024-02-21)
Primary citation	Bourne, C.R.,Barrow, E.W.,Bunce, R.A.,Bourne, P.C.,Berlin, K.D.,Barrow, W.W. Inhibition of Antibiotic-Resistant Staphylococcus aureus by the Broad-Spectrum Dihydrofolate Reductase Inhibitor RAB1. Antimicrob.Agents Chemother., 54:3825-3833, 2010 Cited by PubMed: 20606069 DOI: 10.1128/AAC.00361-10 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.014 Å)

Structure validation