3SGY

Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)

Summary for 3SGY

Entry DOI	10.2210/pdb3sgy/pdb
Related	3F0B 3F0Q 3F0S 3SH2
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-{(3S)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywords	oxidoreductase, nadp, nadph, one-carbon metabolism, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Staphylococcus aureus
Total number of polymer chains	2
Total formula weight	40963.75
Authors	Frey, K.M.,Anderson, A.C. (deposition date: 2011-06-15, release date: 2012-03-07, Last modification date: 2024-04-03)
Primary citation	Viswanathan, K.,Frey, K.M.,Scocchera, E.W.,Martin, B.D.,Swain Iii, P.W.,Alverson, J.B.,Priestley, N.D.,Anderson, A.C.,Wright, D.L. Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes. Plos One, 7:e29434-e29434, 2012 Cited by PubMed: 22347365 DOI: 10.1371/journal.pone.0029434 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.598 Å)

Structure validation