3F0Q

Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine

Summary for 3F0Q

Entry DOI	10.2210/pdb3f0q/pdb
Related	3F0B 3F0S 3F0U 3F0V 3F0X
Descriptor	Trimethoprim-sensitive dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywords	oxidoreductase
Biological source	Staphylococcus aureus RF122
Total number of polymer chains	1
Total formula weight	19147.47
Authors	Anderson, A.C.,Frey, K.M.,Liu, J.,Lombardo, M.N. (deposition date: 2008-10-25, release date: 2009-10-06, Last modification date: 2024-04-03)
Primary citation	Frey, K.M.,Georgiev, I.,Donald, B.R.,Anderson, A.C. Predicting resistance mutations using protein design algorithms. Proc.Natl.Acad.Sci.USA, 107:13707-13712, 2010 Cited by PubMed: 20643959 DOI: 10.1073/pnas.1002162107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation