Functional Information from GO Data
Chain | GOid | namespace | contents |
X | 0004146 | molecular_function | dihydrofolate reductase activity |
X | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
X | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE NDP X 207 |
Chain | Residue |
X | VAL6 |
X | LYS45 |
X | THR46 |
X | LEU62 |
X | THR63 |
X | SER64 |
X | HIS77 |
X | ILE79 |
X | PHE92 |
X | GLY93 |
X | GLY94 |
X | ALA7 |
X | GLN95 |
X | THR96 |
X | LEU97 |
X | GLU100 |
X | THR121 |
X | 52V158 |
X | HOH163 |
X | HOH177 |
X | HOH183 |
X | HOH193 |
X | ILE14 |
X | HOH242 |
X | HOH251 |
X | HOH264 |
X | HOH267 |
X | HOH279 |
X | GLY15 |
X | ASN18 |
X | GLN19 |
X | LEU20 |
X | GLY43 |
X | ARG44 |
site_id | AC2 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 52V X 158 |
Chain | Residue |
X | LEU5 |
X | VAL6 |
X | ALA7 |
X | ASP27 |
X | VAL31 |
X | LYS32 |
X | MET42 |
X | ILE50 |
X | LYS52 |
X | LEU54 |
X | PHE92 |
X | THR111 |
X | HOH159 |
X | HOH193 |
X | NDP207 |
X | HOH264 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
Chain | Residue | Details |
X | VAL13-SER35 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
X | LEU20 | |
X | ASP27 | |