3F0Q
Staphylococcus aureus dihydrofolate reductase complexed with NADPH and 2,4-Diamino-5-[3-(3-methoxy-5-(2,6-dimethylphenyl)phenyl)but-1-ynyl]-6-methylpyrimidine
Summary for 3F0Q
Entry DOI | 10.2210/pdb3f0q/pdb |
Related | 3F0B 3F0S 3F0U 3F0V 3F0X |
Descriptor | Trimethoprim-sensitive dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3S)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (4 entities in total) |
Functional Keywords | oxidoreductase |
Biological source | Staphylococcus aureus RF122 |
Total number of polymer chains | 1 |
Total formula weight | 19147.47 |
Authors | Anderson, A.C.,Frey, K.M.,Liu, J.,Lombardo, M.N. (deposition date: 2008-10-25, release date: 2009-10-06, Last modification date: 2024-04-03) |
Primary citation | Frey, K.M.,Georgiev, I.,Donald, B.R.,Anderson, A.C. Predicting resistance mutations using protein design algorithms. Proc.Natl.Acad.Sci.USA, 107:13707-13712, 2010 Cited by PubMed: 20643959DOI: 10.1073/pnas.1002162107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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