3SGY
Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046452 | biological_process | dihydrofolate metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046655 | biological_process | folic acid metabolic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE NDP A 207 |
Chain | Residue |
A | VAL6 |
A | THR46 |
A | LEU62 |
A | THR63 |
A | SER64 |
A | HIS77 |
A | ILE79 |
A | PHE92 |
A | GLY93 |
A | GLY94 |
A | GLN95 |
A | ALA7 |
A | THR96 |
A | LEU97 |
A | GLU100 |
A | THR121 |
A | 06W168 |
A | ILE14 |
A | ASN18 |
A | GLN19 |
A | LEU20 |
A | GLY43 |
A | ARG44 |
A | LYS45 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 06W A 168 |
Chain | Residue |
A | LEU5 |
A | VAL6 |
A | ALA7 |
A | ASP27 |
A | LEU28 |
A | VAL31 |
A | ILE50 |
A | LEU54 |
A | ASN59 |
A | PHE92 |
A | THR111 |
A | HOH169 |
A | NDP207 |
site_id | AC3 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE NDP B 207 |
Chain | Residue |
B | VAL6 |
B | ALA7 |
B | ILE14 |
B | GLY15 |
B | ASN18 |
B | GLN19 |
B | LEU20 |
B | GLY43 |
B | ARG44 |
B | LYS45 |
B | THR46 |
B | LEU62 |
B | THR63 |
B | SER64 |
B | HIS77 |
B | ILE79 |
B | PHE92 |
B | GLY93 |
B | GLY94 |
B | GLN95 |
B | THR96 |
B | LEU97 |
B | GLU100 |
B | THR121 |
B | 06W168 |
site_id | AC4 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 06W B 168 |
Chain | Residue |
B | LEU5 |
B | VAL6 |
B | ALA7 |
B | ASP27 |
B | LEU28 |
B | VAL31 |
B | MET42 |
B | ILE50 |
B | LEU54 |
B | ASN59 |
B | PHE92 |
B | THR111 |
B | HOH169 |
B | NDP207 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
Chain | Residue | Details |
A | VAL13-SER35 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19280600 |
Chain | Residue | Details |
A | LEU5 | |
B | PHE92 | |
A | ASP27 | |
A | SER49 | |
A | ARG57 | |
A | PHE92 | |
B | LEU5 | |
B | ASP27 | |
B | SER49 | |
B | ARG57 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19280600 |
Chain | Residue | Details |
A | VAL6 | |
B | LEU62 | |
B | GLU100 | |
B | THR121 | |
A | ILE14 | |
A | GLY43 | |
A | LEU62 | |
A | GLU100 | |
A | THR121 | |
B | VAL6 | |
B | ILE14 | |
B | GLY43 |