3S3V
human dihydrofolate reductase Q35K/N64F double mutant binary complex with trimethoprim
Summary for 3S3V
Entry DOI | 10.2210/pdb3s3v/pdb |
Related | 3n0h |
Descriptor | Dihydrofolate reductase, TRIMETHOPRIM, SULFATE ION, ... (4 entities in total) |
Functional Keywords | novel second binding site, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 22444.60 |
Authors | Cody, V.,Pace, J.,Piraino, J.,Queener, S.F. (deposition date: 2011-05-18, release date: 2011-09-28, Last modification date: 2024-02-28) |
Primary citation | Cody, V.,Pace, J.,Piraino, J.,Queener, S.F. Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. J.Struct.Biol., 176:52-59, 2011 Cited by PubMed: 21684339DOI: 10.1016/j.jsb.2011.06.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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