3N0H

hDHFR double mutant Q35S/N64F Trimethoprim Binary Complex

Summary for 3N0H

Entry DOI	10.2210/pdb3n0h/pdb
Related	1U72
Descriptor	Dihydrofolate reductase, TRIMETHOPRIM, SULFATE ION, ... (4 entities in total)
Functional Keywords	double mutant human dihydrofolate reductase trimethoprim, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : P00374
Total number of polymer chains	1
Total formula weight	22210.37
Authors	Cody, V. (deposition date: 2010-05-14, release date: 2011-09-28, Last modification date: 2023-09-06)
Primary citation	Cody, V.,Pace, J.,Piraino, J.,Queener, S.F. Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. J.Struct.Biol., 176:52-59, 2011 Cited by PubMed: 21684339 DOI: 10.1016/j.jsb.2011.06.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation