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3N0H

hDHFR double mutant Q35S/N64F Trimethoprim Binary Complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Dihydrofolate reductasepolymer18621341.51UniProt (P00374)
Pfam (PF00186)
Homo sapiens (human)
2B, F
(A)
TRIMETHOPRIMnon-polymer290.32Chemie (TOP)
3C, D, E
(A)
SULFATE IONnon-polymer96.13Chemie (SO4)
4G
(A)
waterwater18.091Chemie (HOH)
Sequence modifications
A: 1 - 186 (UniProt: P00374)
PDBExternal DatabaseDetails
Ser 35Gln 36engineered mutation
Phe 64Asn 65engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight21341.5
Non-Polymers*Number of molecules5
Total formula weight868.8
All*Total formula weight22210.4
*Water molecules are not included.

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PDB entries from 2025-07-23

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