3S3V
human dihydrofolate reductase Q35K/N64F double mutant binary complex with trimethoprim
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 186 | 21383.6 | 1 | UniProt (P00374) Pfam (PF00186) | Homo sapiens (human) | |
| 2 | B, H (A) | TRIMETHOPRIM | non-polymer | 290.3 | 2 | Chemie (TOP) | |||
| 3 | C, D, E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | I (A) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 1 - 186 (UniProt: P00374)
| PDB | External Database | Details |
|---|---|---|
| Lys 35 | Gln 36 | engineered mutation |
| Phe 64 | Asn 65 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21383.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1061.0 | |
| All* | Total formula weight | 22444.6 |
