3TD8

Structural Analysis of Pneumocystis carinii Dihydrofolate Reductase Complex with NADPH and 2,4-diamino-5-methyl-6-[2'-(4-carboxy-1-pentynyl)-5'-methoxybenzyl]pyrido[2,3-d]pyrimidine

Summary for 3TD8

• Entry DOI: 10.2210/pdb3td8/pdb
• Related: 3cd2
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-{2-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenyl}hex-5-ynoic acid, ... (4 entities in total)
• Functional Keywords: dihydrofolate reductase, oxidoreductase
• Biological source: Pneumocystis carinii
• Total number of polymer chains: 1
• Total formula weight: 25069.41

Authors

Cody, V.,Pace, J.,Stewart, E. (deposition date: 2011-08-10, release date: 2012-04-11, Last modification date: 2023-09-13)

• Primary citation: Cody, V.,Pace, J.,Stewart, E.; Structural analysis of Pneumocystis cariniidihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine.; Acta Crystallogr.,Sect.F, 68:418-423, 2012; PubMed: 22505410; DOI: 10.1107/S1744309112008688

Experimental method

X-RAY DIFFRACTION (1.8 Å)