3CD2
LIGAND INDUCED CONFORMATIONAL CHANGES IN THE CRYSTAL STRUCTURES OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE COMPLEXES WITH FOLATE AND NADP+
Summary for 3CD2
Entry DOI | 10.2210/pdb3cd2/pdb |
Related | 1CD2 2CD2 4CD2 |
Descriptor | DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (4 entities in total) |
Functional Keywords | oxido-reductase, methotrexate, nadph, oxidoreductase |
Biological source | Pneumocystis carinii |
Total number of polymer chains | 1 |
Total formula weight | 25116.38 |
Authors | Cody, V.,Galitsky, N.,Rak, D.,Luft, J.,Pangborn, W.,Queener, S. (deposition date: 1999-03-16, release date: 2000-03-29, Last modification date: 2023-12-27) |
Primary citation | Cody, V.,Galitsky, N.,Rak, D.,Luft, J.R.,Pangborn, W.,Queener, S.F. Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+. Biochemistry, 38:4303-4312, 1999 Cited by PubMed: 10194348DOI: 10.1021/bi982728m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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