3SH2
Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)pyrimidine-2,4-diamine (UCP120J)
Summary for 3SH2
Entry DOI | 10.2210/pdb3sh2/pdb |
Related | 3F0B 3F0Q 3F0S 3SGY |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-[3-(4-methoxybiphenyl-3-yl)prop-1-yn-1-yl]pyrimidine-2,4-diamine (3 entities in total) |
Functional Keywords | oxidoreductase, nadp, nadph, one-carbon metabolism, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 2 |
Total formula weight | 40933.72 |
Authors | Frey, K.M.,Anderson, A.C. (deposition date: 2011-06-15, release date: 2012-03-07, Last modification date: 2024-04-03) |
Primary citation | Viswanathan, K.,Frey, K.M.,Scocchera, E.W.,Martin, B.D.,Swain Iii, P.W.,Alverson, J.B.,Priestley, N.D.,Anderson, A.C.,Wright, D.L. Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes. Plos One, 7:e29434-e29434, 2012 Cited by PubMed: 22347365DOI: 10.1371/journal.pone.0029434 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.999 Å) |
Structure validation
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