3SH2
Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ethyl-5-(3-(4-methoxybiphenyl-3-yl)prop-1-ynyl)pyrimidine-2,4-diamine (UCP120J)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070401 | molecular_function | NADP+ binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0044281 | biological_process | small molecule metabolic process |
| B | 0046452 | biological_process | dihydrofolate metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046655 | biological_process | folic acid metabolic process |
| B | 0050661 | molecular_function | NADP binding |
| B | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NDP A 207 |
| Chain | Residue |
| A | VAL6 |
| A | LYS45 |
| A | THR46 |
| A | LEU62 |
| A | THR63 |
| A | SER64 |
| A | HIS77 |
| A | PHE92 |
| A | GLY94 |
| A | GLN95 |
| A | THR96 |
| A | ALA7 |
| A | LEU97 |
| A | GLU100 |
| A | THR121 |
| A | 5DR168 |
| A | ILE14 |
| A | GLY15 |
| A | ASN18 |
| A | GLN19 |
| A | LEU20 |
| A | GLY43 |
| A | ARG44 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NDP B 207 |
| Chain | Residue |
| B | VAL6 |
| B | ALA7 |
| B | ILE14 |
| B | GLY15 |
| B | ASN18 |
| B | GLN19 |
| B | LEU20 |
| B | GLY43 |
| B | ARG44 |
| B | LYS45 |
| B | THR46 |
| B | LEU62 |
| B | THR63 |
| B | SER64 |
| B | HIS77 |
| B | PHE92 |
| B | GLY94 |
| B | GLN95 |
| B | THR96 |
| B | LEU97 |
| B | GLU100 |
| B | THR121 |
| B | 5DR168 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 5DR A 168 |
| Chain | Residue |
| A | LEU5 |
| A | VAL6 |
| A | ALA7 |
| A | LEU20 |
| A | ASP27 |
| A | LEU28 |
| A | VAL31 |
| A | SER49 |
| A | ILE50 |
| A | PHE92 |
| A | THR111 |
| A | NDP207 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 5DR B 168 |
| Chain | Residue |
| B | LEU5 |
| B | VAL6 |
| B | ALA7 |
| B | ASP27 |
| B | LEU28 |
| B | VAL31 |
| B | ILE50 |
| B | PHE92 |
| B | THR111 |
| B | NDP207 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGfenqLPWhlpn.DlkhVkklS |
| Chain | Residue | Details |
| A | VAL13-SER35 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 310 |
| Details | Domain: {"description":"DHFR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00660","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19280600","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19280600","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
