PDB: 663 件ウェブページステータス検索Chemie searchBIRD

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4LZ8	Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide, ... 著者 Pandit, J. 登録日 2013-07-31 公開日 2013-12-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators. J.Med.Chem., 56, 2013
4MF3	Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist 分子名称: (3S,4aS,6S,8aR)-6-[3-chloro-2-(1H-tetrazol-5-yl)phenoxy]decahydroisoquinoline-3-carboxylic acid, Glutamate receptor ionotropic, kainate 1 著者 Martinez-Perez, J.A, Iyengar, S, Shannon, H.E, Bleakman, D, Alt, A, Clawson, D.K, Arnold, B.M, Bell, M.G, Bleisch, T.J, Castano, A.M, Del Prado, M, Dominguez, E, Escribano, A.M, Filla, S.A, Ho, K.H, Hudziak, K.J, Jones, C.K, Katofiasc, M.A, Mateo, A, Mathes, B.M, Mattiuz, E.L, Ogden, A.M.L, Phebus, L.A, Simmons, R.M.A, Stack, D.R, Stratford, R.E, Winter, M.A, Wu, Z, Ornstein, P.L. 登録日 2013-08-27 公開日 2014-05-07 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy. Bioorg.Med.Chem.Lett., 23, 2013
4MH5	Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate 分子名称: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ... 著者 Venskutonyte, R, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2013-08-29 公開日 2013-10-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. J.Struct.Biol., 176, 2011
4N07	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution 分子名称: 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, CACODYLATE ION, ... 著者 Noerholm, A.B, Frydenvang, K, Kastrup, J.S. 登録日 2013-10-01 公開日 2013-11-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Synthesis, pharmacological and structural characterization, and thermodynamic aspects of GluA2-positive allosteric modulators with a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide scaffold. J.Med.Chem., 56, 2013
4NF6	Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and PPDA 分子名称: (2S,3R)-1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid, GLYCINE, Glutamate receptor ionotropic, ... 著者 Jespersen, A, Tajima, N, Furukawa, H. 登録日 2013-10-30 公開日 2014-03-12 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
4NF8	Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and glutamate in PEG2000MME 分子名称: GLUTAMIC ACID, GLYCINE, Glutamate receptor ionotropic, ... 著者 Jespersen, A, Tajima, N, Furukawa, H. 登録日 2013-10-30 公開日 2014-03-12 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (1.856 Å) 主引用文献 Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
4NF4	Crystal structure of GluN1/GluN2A ligand-binding domain in complex with DCKA and glutamate 分子名称: 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, GLUTAMIC ACID, Glutamate receptor ionotropic, ... 著者 Annie, J, Tajima, N, Furukawa, H. 登録日 2013-10-30 公開日 2014-03-12 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
4NF5	Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5 分子名称: 5-phosphono-D-norvaline, GLYCEROL, GLYCINE, ... 著者 Jespersen, A, Tajima, N, Furukawa, H. 登録日 2013-10-30 公開日 2014-03-12 最終更新日 2017-08-09 実験手法 X-RAY DIFFRACTION (1.903 Å) 主引用文献 Structural Insights into Competitive Antagonism in NMDA Receptors. Neuron, 81, 2014
4NWD	Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist (2S,4R)-4-(3-Methylamino-3-oxopropyl)glutamic acid at 2.6 A resolution 分子名称: (4R)-4-[3-(methylamino)-3-oxopropyl]-L-glutamic acid, CHLORIDE ION, Glutamate receptor ionotropic, ... 著者 Venskutonyte, R, Larsen, A.P, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2013-12-06 公開日 2014-08-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain. Chemmedchem, 9, 2014
4NWC	Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic acid at 2.01 A resolution. 分子名称: (2S,4R)-4-(3-Methoxy-3-oxopropyl) glutamic acid, CHLORIDE ION, Glutamate receptor ionotropic, ... 著者 Larsen, A.P, Venskutonyte, R, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2013-12-06 公開日 2014-08-06 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.012 Å) 主引用文献 Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain. Chemmedchem, 9, 2014
4O3A	Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution 分子名称: ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ... 著者 Krintel, C, Frydenvang, F, Gajhede, M, Kastrup, J.S. 登録日 2013-12-18 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
4O3B	Crystal structure of an open/closed glua2 ligand-binding domain dimer at 1.91 A resolution 分子名称: ACETATE ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Krintel, C, de Rabassa, A.C, Frydenvang, K, Gajhede, M, Kastrup, J.S. 登録日 2013-12-18 公開日 2014-04-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.906 Å) 主引用文献 L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
4O3C	Crystal structure of the GLUA2 ligand-binding domain in complex with L-aspartate at 1.50 A resolution 分子名称: ACETATE ION, ASPARTIC ACID, CHLORIDE ION, ... 著者 Krintel, C, Frydenvang, K, Kaern, A.M, Gajhede, M, Kastrup, J.S. 登録日 2013-12-18 公開日 2014-04-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain. Febs J., 281, 2014
4Q30	Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5 分子名称: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2 CHIMERIC PROTEIN, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2014-04-10 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development. Biochemistry, 53, 2014
4PE5	Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ... 著者 Karakas, E, Furukawa, H. 登録日 2014-04-22 公開日 2014-06-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.96 Å) 主引用文献 Crystal structure of a heterotetrameric NMDA receptor ion channel. Science, 344, 2014
4QF9	Structure of GluK1 ligand-binding domain (S1S2) in complex with (S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid at 2.28 A resolution 分子名称: (2S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid, ACETATE ION, CHLORIDE ION, ... 著者 Kristensen, C.M, Frydenvang, K, Kastrup, J.S. 登録日 2014-05-20 公開日 2015-04-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Binding Mode of an alpha-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1. ACS Chem Neurosci, 6, 2015
4TLL	Crystal structure of GluN1/GluN2B NMDA receptor, structure 1 分子名称: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... 著者 Gouaux, E, Lee, C.-H, Lu, W. 登録日 2014-05-30 公開日 2014-07-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.59 Å) 主引用文献 NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
4TLM	Crystal structure of GluN1/GluN2B NMDA receptor, structure 2 分子名称: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... 著者 Gouaux, E, Lee, C.-H, Lu, W. 登録日 2014-05-30 公開日 2014-07-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.77 Å) 主引用文献 NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
4UQ6	Electron density map of GluA2em in complex with LY451646 and glutamate 分子名称: GLUTAMATE RECEPTOR 2, GLUTAMIC ACID 著者 Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S. 登録日 2014-06-20 公開日 2014-08-13 最終更新日 2017-08-02 実験手法 ELECTRON MICROSCOPY (12.8 Å) 主引用文献 Structural Mechanism of Glutamate Receptor Activation and Desensitization Nature, 514, 2014
4UQK	Electron density map of GluA2em in complex with quisqualate and LY451646 分子名称: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2 著者 Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S. 登録日 2014-06-24 公開日 2014-08-13 最終更新日 2017-08-02 実験手法 ELECTRON MICROSCOPY (16.4 Å) 主引用文献 Structural Mechanism of Glutamate Receptor Activation and Desensitization Nature, 514, 2014
4UQQ	Electron density map of GluK2 desensitized state in complex with 2S,4R-4-methylglutamate 分子名称: GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2, GLUTAMIC ACID 著者 Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S. 登録日 2014-06-24 公開日 2014-08-13 最終更新日 2017-08-02 実験手法 ELECTRON MICROSCOPY (7.6 Å) 主引用文献 Structural Mechanism of Glutamate Receptor Activation and Desensitization Nature, 514, 2014
4UQJ	Cryo-EM density map of GluA2em in complex with ZK200775 分子名称: GLUTAMATE RECEPTOR 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid 著者 Meyerson, J.R, Kumar, J, Chittori, S, Rao, P, Pierson, J, Bartesaghi, A, Mayer, M.L, Subramaniam, S. 登録日 2014-06-24 公開日 2014-08-13 最終更新日 2017-08-02 実験手法 ELECTRON MICROSCOPY (10.4 Å) 主引用文献 Structural Mechanism of Glutamate Receptor Activation and Desensitization Nature, 514, 2014
4U1O	GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form C 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide 著者 Chen, L, Gouaux, E. 登録日 2014-07-15 公開日 2014-08-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8501 Å) 主引用文献 Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
4U1W	Full length GluA2-kainate-(R,R)-2b complex crystal form A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ... 著者 Chen, L, Gouaux, E. 登録日 2014-07-16 公開日 2014-08-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014
4U1X	Full length GluA2-kainate-(R,R)-2b complex crystal form B 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, ... 著者 Chen, L, Gouaux, E. 登録日 2014-07-16 公開日 2014-08-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.301 Å) 主引用文献 Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell, 158, 2014

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