4Y9F
| Crystal structure of V30M mutated transthyretin with bromide in complex with gamma-mangostin | 分子名称: | 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, BROMIDE ION, Transthyretin | 著者 | Yokoyama, T, Mizuguchi, M. | 登録日 | 2015-02-17 | 公開日 | 2015-09-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor Sci Rep, 5, 2015
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4Y9E
| Crystal structure of V30M mutated transthyretin in complex with gamma-mangostin | 分子名称: | 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, CHLORIDE ION, Transthyretin | 著者 | Yokoyama, T, Mizuguchi, M. | 登録日 | 2015-02-17 | 公開日 | 2015-09-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor Sci Rep, 5, 2015
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6Y58
| Binary complex of 14-3-3 sigma (C38N) with the Estrogen Related Receptor gamma (LBD) phosphopeptide | 分子名称: | 14-3-3 protein sigma, Estrogen Related Receptor gamma phosphopeptide, MAGNESIUM ION | 著者 | Somsen, B.A, Sijbesma, E, Leijten-van de Gevel, I.A, Ottmann, C. | 登録日 | 2020-02-25 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | 主引用文献 | Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
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6Y18
| Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 3 | 分子名称: | 14-3-3 protein sigma, 4-fluoranyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide, CHLORIDE ION, ... | 著者 | Somsen, B.A, Ottmann, C. | 登録日 | 2020-02-11 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
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2P3V
| Thermotoga maritima IMPase TM1415 | 分子名称: | Inositol-1-monophosphatase, S,R MESO-TARTARIC ACID | 著者 | Stieglitz, K.A, Roberts, M.F, Li, W, Stec, B. | 登録日 | 2007-03-09 | 公開日 | 2007-04-24 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima. Febs J., 274, 2007
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6VG5
| DengueV-2 Capsid ST148 inhibitor Complex | 分子名称: | 3-amino-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]thieno[3,2-e]pyridine-2-carboxamide, Capsid premembrane protein, GLYCEROL, ... | 著者 | White, M, Xia, H, Shi, P. | 登録日 | 2020-01-07 | 公開日 | 2020-07-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A cocrystal structure of dengue capsid protein in complex of inhibitor. Proc.Natl.Acad.Sci.USA, 117, 2020
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6XXC
| Ternary complex of 14-3-3 sigma (C38N), Estrogen Related Receptor gamma (DBD) phosphopeptide, and disulfide PPI stabilizer 4 | 分子名称: | 14-3-3 protein sigma, CHLORIDE ION, Estrogen Related Receptor gamma phosphopeptide, ... | 著者 | Somsen, B.A, Ottmann, C. | 登録日 | 2020-01-27 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. Acs Chem.Biol., 15, 2020
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8JBB
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8SDI
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6SPW
| Structure of protein kinase CK2 catalytic subunit with the CK2beta-competitive bisubstrate inhibitor ARC3140 | 分子名称: | 8-[4,5,6,7-tetrakis(iodanyl)benzimidazol-1-yl]octanoic acid, ARC3140, Casein kinase II subunit alpha, ... | 著者 | Niefind, K, Schnitzler, A. | 登録日 | 2019-09-03 | 公開日 | 2020-01-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Unexpected CK2 beta-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2. Bioorg.Chem., 96, 2020
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3QW4
| Structure of Leishmania donovani UMP synthase | 分子名称: | CHLORIDE ION, UMP synthase, URIDINE-5'-MONOPHOSPHATE | 著者 | French, J.B, Ealick, S.E. | 登録日 | 2011-02-26 | 公開日 | 2011-04-20 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization. J.Biol.Chem., 286, 2011
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8ELO
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8ELQ
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8ELP
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7L28
| Crystal structure of the catalytic domain of human PDE3A bound to Trequinsin | 分子名称: | (2E)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one, ACETATE ION, MAGNESIUM ION, ... | 著者 | Horner, S.W, Garvie, C. | 登録日 | 2020-12-16 | 公開日 | 2021-06-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nat Commun, 12, 2021
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7FIS
| The crystal structure of beta-1,2-mannobiose phosphorylase in complex with mannose 1-phosphate (M1P) | 分子名称: | 1-O-phosphono-alpha-D-mannopyranose, Beta-1,2-mannobiose phosphorylase, GLYCEROL, ... | 著者 | Dai, L, Chang, Z, Yang, J, Liu, W, Yang, Y, Chen, C.-C, Zhang, L, Huang, J, Sun, Y, Guo, R.-T. | 登録日 | 2021-08-01 | 公開日 | 2022-01-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structural investigation of a thermostable 1,2-beta-mannobiose phosphorylase from Thermoanaerobacter sp. X-514. Biochem.Biophys.Res.Commun., 579, 2021
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1XPH
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6WHY
| GluN1b-GluN2B NMDA receptor in complex with GluN1 antagonist L689,560, class 1 | 分子名称: | (2R,4S)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Chou, T, Tajima, N, Furukawa, H. | 登録日 | 2020-04-08 | 公開日 | 2020-07-15 | 最終更新日 | 2020-08-05 | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | 主引用文献 | Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell, 182, 2020
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4WY4
| Crystal structure of autophagic SNARE complex | 分子名称: | Synaptosomal-associated protein 29, Syntaxin-17, Vesicle-associated membrane protein 8 | 著者 | Zhao, M, Brunger, A.T. | 登録日 | 2014-11-15 | 公開日 | 2015-02-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature, 520, 2015
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7FWZ
| Crystal Structure of human FABP4 in complex with 4-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]pyrazol-1-yl]butanoic acid | 分子名称: | 4-[3-(trifluoromethyl)-5,6,7,8-tetrahydrocyclohepta[c]pyrazol-1(4H)-yl]butanoic acid, FORMIC ACID, Fatty acid-binding protein, ... | 著者 | Ehler, A, Benz, J, Obst, U, Brunner, M, Rudolph, M.G. | 登録日 | 2023-04-27 | 公開日 | 2023-06-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Crystal Structure of a human FABP4 complex To be published
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3KGU
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6ZAD
| PI3K Delta in complex with methoxymethyloxathiatetraazatetracyclodocosahexaenedione | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, methoxymethyloxathiatetraazatetracyclodocosahexaenedione | 著者 | Convery, M.A, Hardy, C.J, Spencer, J.A, Rowland, P. | 登録日 | 2020-06-05 | 公開日 | 2020-07-29 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase delta. Acs Med.Chem.Lett., 11, 2020
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8BYO
| fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361) | 分子名称: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | 著者 | Visser, E.J, Vandenboorn, E.M.F, Ottmann, C. | 登録日 | 2023-01-18 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BZW
| Co-soaked stabilizers for ERa - 14-3-3 interaction (844_AZ210) | 分子名称: | 14-3-3 protein sigma, 2-(4-chloranylphenoxy)-2-methyl-~{N}-(2-sulfanylethyl)propanamide, 4-[(2~{R})-3-azanyl-2-methyl-propyl]-7-methoxy-1-benzothiophene-2-carboximidamide, ... | 著者 | Visser, E.J, Sijbesma, E, Ottmann, C. | 登録日 | 2022-12-15 | 公開日 | 2023-08-02 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8BYE
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