6ZAD

PI3K Delta in complex with methoxymethyloxathiatetraazatetracyclodocosahexaenedione

Summary for 6ZAD

Entry DOI	10.2210/pdb6zad/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, methoxymethyloxathiatetraazatetracyclodocosahexaenedione (3 entities in total)
Functional Keywords	macrocycle, pi3k delta, thermodynamics, transferase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	108214.12
Authors	Convery, M.A.,Hardy, C.J.,Spencer, J.A.,Rowland, P. (deposition date: 2020-06-05, release date: 2020-07-29, Last modification date: 2021-09-29)
Primary citation	Spencer, J.A.,Baldwin, I.R.,Barton, N.,Chung, C.W.,Convery, M.A.,Edwards, C.D.,Jamieson, C.,Mallett, D.N.,Rowedder, J.E.,Rowland, P.,Thomas, D.A.,Hardy, C.J. Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3-Kinase delta. Acs Med.Chem.Lett., 11:1386-1391, 2020 Cited by PubMed: 32676144 DOI: 10.1021/acsmedchemlett.0c00061 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation