PDB: 42250 件ウェブページステータス検索Chemie searchBIRD

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6C7X	Carbonic anhydrase 2 in complex with 2-chloro-5'-O-sulfamoyladenosine 分子名称: 2-chloro-5'-O-sulfamoyladenosine, Carbonic anhydrase 2, SODIUM ION, ... 著者 Peat, T.S, Mujumdar, P, Poulsen, S.A. 登録日 2018-01-23 公開日 2018-05-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Synthesis, structure and bioactivity of primary sulfamate-containing natural products. Bioorg. Med. Chem. Lett., 28, 2018
7Q1I	Hybrid form of uridine phosphorylase from E. coli and Salmonella typhimurium in the presence glycerol 分子名称: CITRATE ANION, GLYCEROL, POTASSIUM ION, ... 著者 Polyakov, K, Safonova, T. 登録日 2021-10-20 公開日 2022-04-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Hybrid form of uridine phosphorylase from E. coli and Salmonella typhimurium in the presence glycerol To Be Published
8SPB	Caspase-4/Pro-IL-18 complex 分子名称: Caspase-4 subunit p10, Caspase-4 subunit p20, Interleukin-18 著者 Pascal, D, Dong, Y, Wu, H, Jon, K. 登録日 2023-05-02 公開日 2023-11-22 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural insights into cytokine cleavage by inflammatory caspase-4. Nature, 624, 2023
6C8R	Loganic acid O-methyltransferase complexed with SAH and loganic acid 分子名称: Loganic acid, Loganic acid O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE 著者 Petronikolou, N, Nair, S.K. 登録日 2018-01-25 公開日 2018-02-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.951 Å) 主引用文献 Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside. Chembiochem, 19, 2018
4PGV	Crystal structure of YetJ from Bacillus Subtilis at pH 8 by back soaking 分子名称: Uncharacterized protein YetJ 著者 Liu, Q, Chang, Y, Hendrickson, W.A, New York Consortium on Membrane Protein Structure (NYCOMPS) 登録日 2014-05-02 公開日 2014-06-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Structural basis for a pH-sensitive calcium leak across membranes. Science, 344, 2014
8SBK	Structure of HLA-A*24:02 in complex with peptide, LYLPVRVLI (ATG2A). 分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, LEU-TYR-LEU-PRO-VAL-ARG-VAL-LEU-ILE, ... 著者 Mallik, L, Young, M.C, Sgourakis, N.G. 登録日 2023-04-03 公開日 2023-12-06 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Sci Immunol, 8, 2023
8SBL	Structure of HLA-A*24:02 in complex with peptide, LYLPVRVLI 分子名称: Beta-2-microglobulin, LEU-TYR-LEU-PRO-VAL-ARG-VAL-LEU-ILE, MHC class I antigen 著者 Mallik, L, Young, M.C, Sgourakis, N.G. 登録日 2023-04-03 公開日 2023-12-06 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion. Sci Immunol, 8, 2023
6C6R	Human Squalene Epoxidase (SQLE, Squalene Monooxygenase) structure with FAD 分子名称: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, DI(HYDROXYETHYL)ETHER, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Padyana, A.K, Jin, L. 登録日 2018-01-19 公開日 2019-01-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun, 10, 2019
6UT4	Cryo-EM structure of the asymmetric AAA+ domain hexamer from Thermococcus gammatolerans McrB 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase subunit of restriction endonuclease, MAGNESIUM ION 著者 Niu, Y, Suzuki, H, Hosford, C.J, Chappie, J.S, Walz, T. 登録日 2019-10-29 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes. Nat Commun, 11, 2020
8SOS	Human CD1d presenting sphingomyelin C24:1 in complex with VHH nanobody 1D17 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d, Beta-2-microglobulin, ... 著者 Shahine, A, Rossjohn, J. 登録日 2023-04-29 公開日 2023-12-13 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions. J Immunother Cancer, 11, 2023
5BPC	DNA polymerase beta ternary complex with a templating 5ClC and incoming dATP analog 分子名称: 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, DNA (5'-D(*CP*CP*GP*AP*CP*(CDO)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... 著者 Freudenthal, B.D, Wilson, S.H. 登録日 2015-05-28 公開日 2015-08-19 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer. Proc.Natl.Acad.Sci.USA, 112, 2015
6CA2	ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II 分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION 著者 Alexander, R.S, Christianson, D.W. 登録日 1991-07-09 公開日 1992-07-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Engineering the hydrophobic pocket of carbonic anhydrase II. Biochemistry, 30, 1991
6CB1	Yeast nucleolar pre-60S ribosomal subunit (state 3) 分子名称: 35S pre-ribosomal RNA miscRNA, 5.8S rRNA, 60S ribosomal protein L13-A, ... 著者 Sanghai, Z.A, Miller, L, Barandun, J, Hunziker, M, Chaker-Margot, M, Klinge, S. 登録日 2018-02-01 公開日 2018-03-14 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Modular assembly of the nucleolar pre-60S ribosomal subunit. Nature, 556, 2018
6USS	Catalytic S88C mutant of gut microbial sulfatase from Bacteroides fragilis CAG:558 分子名称: CALCIUM ION, Sulfatase 著者 Ervin, S.M, Redinbo, M.R. 登録日 2019-10-28 公開日 2020-11-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases. Biochemistry, 59, 2020
6UT7	Fitted model for the tetradecameric assembly of Thermococcus gammatolerans McrB AAA+ hexamers with bound McrC 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase subunit of restriction endonuclease, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Niu, Y, Suzuki, H, Hosford, C.J, Chappie, J.S, Walz, T. 登録日 2019-10-29 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.26 Å) 主引用文献 Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes. Nat Commun, 11, 2020
6DHU	Crystal structure of Tdp1 catalytic domain in complex with Zenobia fragment ZT0911 from cocktail soak 分子名称: 1,2-ETHANEDIOL, Tyrosyl-DNA phosphodiesterase 1, benzene-1,2,4-tricarboxylic acid 著者 Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. 登録日 2018-05-21 公開日 2019-05-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019
7QGZ	Human carbonic anhydrase II in complex with Methyl 3-((4-methylthiazol-2-yl)(4-sulfamoylphenyl)amino)propanoate 分子名称: Carbonic anhydrase 2, ZINC ION, methyl 3-[(4-methyl-1,3-thiazol-2-yl)-(4-sulfamoylphenyl)amino]propanoate 著者 Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S. 登録日 2021-12-10 公開日 2022-05-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases. Pharmaceuticals, 15, 2022
6UUL	Crystal structure of broad and potent HIV-1 neutralizing antibody 438-D5 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, D5 Fab Heavy Chain, ... 著者 Kumar, S, Wilson, I.A. 登録日 2019-10-30 公開日 2020-09-23 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 A V H 1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite. Sci Adv, 6, 2020
5BOM	DNA polymerase beta binary complex with a templating 5ClC 分子名称: DNA (5'-D(*CP*CP*GP*AP*CP*(4U3)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... 著者 Freudenthal, B.D, Wilson, S.H. 登録日 2015-05-27 公開日 2015-08-19 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.0002 Å) 主引用文献 Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer. Proc.Natl.Acad.Sci.USA, 112, 2015
6DIE	Crystal structure of Tdp1 catalytic domain in complex with Zenobia fragment benzene-1,2,4-tricarboxylic acid from single soak 分子名称: 1,2-ETHANEDIOL, Tdp1 catalytic domain (residues 149-609), benzene-1,2,4-tricarboxylic acid 著者 Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. 登録日 2018-05-23 公開日 2019-05-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019
5BOY	X-RAY Co-structure of MMP-13 with ethyl 5-(1-methyl-1H-imidazol-5-yl)-1H-indole-2-Carboxylate 分子名称: CALCIUM ION, Collagenase 3, ZINC ION, ... 著者 Farrow, N.A. 登録日 2015-05-27 公開日 2015-06-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J. Med. Chem., 54, 2011
7QGY	Human carbonic anhydrase II in complex with 3-((5-(ethoxycarbonyl)-4-methylthiazol-2-yl)(4-sulfamoylphenyl)amino)propanoic acid 分子名称: 3-[(5-ethoxycarbonyl-4-methyl-1,3-thiazol-2-yl)-(4-sulfamoylphenyl)amino]propanoic acid, Carbonic anhydrase 2, ZINC ION 著者 Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S. 登録日 2021-12-10 公開日 2022-05-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases. Pharmaceuticals, 15, 2022
5BV7	Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 27C3 heavy chain, 27C3 light chain, ... 著者 Piper, D.E, Romanow, W.G, Thibault, S.T, Walker, N.P.C. 登録日 2015-06-04 公開日 2015-12-16 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism. J.Biol.Chem., 291, 2016
7QGX	Human carbonic anhydrase II in complex with 3-((5-chloro-4-(4-chlorophenyl)thiazol-2-yl)(4-sulfamoylphenyl)amino)propanoic acid 分子名称: 3-[[5-chloranyl-4-(4-chlorophenyl)-1,3-thiazol-2-yl]-(4-sulfamoylphenyl)amino]propanoic acid, Carbonic anhydrase 2, MALONATE ION, ... 著者 Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S. 登録日 2021-12-10 公開日 2022-05-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases. Pharmaceuticals, 15, 2022
6DJ3	Crystal structure of CNNM2 cyclic nucleotide-binding homology domain 分子名称: 1,2-ETHANEDIOL, Metal transporter CNNM2 著者 Chen, Y.S, Gehring, K. 登録日 2018-05-24 公開日 2018-10-31 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The cyclic nucleotide-binding homology domain of the integral membrane protein CNNM mediates dimerization and is required for Mg2+efflux activity. J. Biol. Chem., 293, 2018

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