5BV7

Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody

Summary for 5BV7

• Entry DOI: 10.2210/pdb5bv7/pdb
• Descriptor: Phosphatidylcholine-sterol acyltransferase, 27C3 light chain, 27C3 heavy chain, ... (8 entities in total)
• Functional Keywords: a/b hydrolase, immune system, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 145522.37

Authors

Piper, D.E.,Romanow, W.G.,Thibault, S.T.,Walker, N.P.C. (deposition date: 2015-06-04, release date: 2015-12-16, Last modification date: 2023-09-27)

• Primary citation: Gunawardane, R.N.,Fordstrom, P.,Piper, D.E.,Masterman, S.,Siu, S.,Liu, D.,Brown, M.,Lu, M.,Tang, J.,Zhang, R.,Cheng, J.,Gates, A.,Meininger, D.,Chan, J.,Carlson, T.,Walker, N.,Schwarz, M.,Delaney, J.,Zhou, M.; Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism.; J.Biol.Chem., 291:2799-2811, 2016; PubMed: 26644477; DOI: 10.1074/jbc.M115.672790

Experimental method

X-RAY DIFFRACTION (2.45 Å)