5BV7
Crystal structure of human LCAT (L4F, N5D) in complex with Fab of an agonistic antibody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003847 | molecular_function | 1-alkyl-2-acetylglycerophosphocholine esterase activity |
| A | 0004607 | molecular_function | phosphatidylcholine-sterol O-acyltransferase activity |
| A | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| A | 0004771 | molecular_function | sterol ester esterase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008203 | biological_process | cholesterol metabolic process |
| A | 0008374 | molecular_function | O-acyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030301 | biological_process | cholesterol transport |
| A | 0034186 | molecular_function | apolipoprotein A-I binding |
| A | 0034364 | cellular_component | high-density lipoprotein particle |
| A | 0034372 | biological_process | very-low-density lipoprotein particle remodeling |
| A | 0034375 | biological_process | high-density lipoprotein particle remodeling |
| A | 0042157 | biological_process | lipoprotein metabolic process |
| A | 0042632 | biological_process | cholesterol homeostasis |
| A | 0043691 | biological_process | reverse cholesterol transport |
| A | 0046470 | biological_process | phosphatidylcholine metabolic process |
| A | 0046688 | biological_process | response to copper ion |
| A | 0047179 | molecular_function | platelet-activating factor acetyltransferase activity |
| A | 0051384 | biological_process | response to glucocorticoid |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0090107 | biological_process | regulation of high-density lipoprotein particle assembly |
Functional Information from PROSITE/UniProt
| site_id | PS00120 |
| Number of Residues | 10 |
| Details | LIPASE_SER Lipases, serine active site. VFLIGHSLGC |
| Chain | Residue | Details |
| A | VAL175-CYS184 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH |
| Chain | Residue | Details |
| L | TYR193-HIS199 | |
| B | TYR192-HIS198 | |
| C | TYR207-HIS213 | |
| H | TYR207-HIS213 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Determinant for substrate specificity","evidences":[{"source":"PubMed","id":"14636062","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7613477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4X96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7613477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4X96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
