5BOY

X-RAY Co-structure of MMP-13 with ethyl 5-(1-methyl-1H-imidazol-5-yl)-1H-indole-2-Carboxylate

Summary for 5BOY

• Entry DOI: 10.2210/pdb5boy/pdb
• Related: 5BPA
• Descriptor: Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: ridgefield, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted, extracellular space, extracellular matrix : P45452
• Total number of polymer chains: 2
• Total formula weight: 39511.47

Authors

Farrow, N.A. (deposition date: 2015-05-27, release date: 2015-06-17, Last modification date: 2024-03-06)

• Primary citation: Taylor, S.J.,Abeywardane, A.,Liang, S.,Muegge, I.,Padyana, A.K.,Xiong, Z.,Hill-Drzewi, M.,Farmer, B.,Li, X.,Collins, B.,Li, J.X.,Heim-Riether, A.,Proudfoot, J.,Zhang, Q.,Goldberg, D.,Zuvela-Jelaska, L.,Zaher, H.,Li, J.,Farrow, N.A.; Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13.; J. Med. Chem., 54:8174-8187, 2011; PubMed: 22017539; DOI: 10.1021/jm201129m

Experimental method

X-RAY DIFFRACTION (2.03 Å)