5BPA
X-RAY Co-structure of MMP-13 with 4-[({5-[2-(ethoxycarbonyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}formamido)methyl]benzoate
Summary for 5BPA
Entry DOI | 10.2210/pdb5bpa/pdb |
Related | 5BOY |
Descriptor | Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | ridgefield, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P45452 |
Total number of polymer chains | 2 |
Total formula weight | 39865.78 |
Authors | Farrow, N.A.,Margarit, S.M. (deposition date: 2015-05-27, release date: 2015-06-17, Last modification date: 2024-03-06) |
Primary citation | Taylor, S.J.,Abeywardane, A.,Liang, S.,Muegge, I.,Padyana, A.K.,Xiong, Z.,Hill-Drzewi, M.,Farmer, B.,Li, X.,Collins, B.,Li, J.X.,Heim-Riether, A.,Proudfoot, J.,Zhang, Q.,Goldberg, D.,Zuvela-Jelaska, L.,Zaher, H.,Li, J.,Farrow, N.A. Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J. Med. Chem., 54:8174-8187, 2011 Cited by PubMed: 22017539DOI: 10.1021/jm201129m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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