5BPA

X-RAY Co-structure of MMP-13 with 4-[({5-[2-(ethoxycarbonyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}formamido)methyl]benzoate

Summary for 5BPA

• Entry DOI: 10.2210/pdb5bpa/pdb
• Related: 5BOY
• Descriptor: Collagenase 3, ZINC ION, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: ridgefield, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted, extracellular space, extracellular matrix : P45452
• Total number of polymer chains: 2
• Total formula weight: 39865.78

Authors

Farrow, N.A.,Margarit, S.M. (deposition date: 2015-05-27, release date: 2015-06-17, Last modification date: 2024-03-06)

• Primary citation: Taylor, S.J.,Abeywardane, A.,Liang, S.,Muegge, I.,Padyana, A.K.,Xiong, Z.,Hill-Drzewi, M.,Farmer, B.,Li, X.,Collins, B.,Li, J.X.,Heim-Riether, A.,Proudfoot, J.,Zhang, Q.,Goldberg, D.,Zuvela-Jelaska, L.,Zaher, H.,Li, J.,Farrow, N.A.; Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13.; J. Med. Chem., 54:8174-8187, 2011; PubMed: 22017539; DOI: 10.1021/jm201129m

Experimental method

X-RAY DIFFRACTION (1.79 Å)