PDB: 31171 件ウェブページステータス検索Chemie searchBIRD

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6CD6	Crystal Structure of the Human CAMKK1A in complex with GSK650394 分子名称: 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid, CHLORIDE ION, Calcium/calmodulin-dependent protein kinase kinase 1 著者 Santiago, A.S, Counago, R.M, Righetto, G.L, Ramos, P.Z, Silva, P.N.B, Drewry, D, Elkins, J.M, Massirer, K.B, Arruda, P, Edwards, A.M, Structural Genomics Consortium (SGC) 登録日 2018-02-08 公開日 2018-03-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of the Human CAMKK1A in complex with GSK650394 To be Published
6CDG	GID4 fragment in complex with a peptide 分子名称: Glucose-induced degradation protein 4 homolog, Hexapeptide PGLWKS, UNKNOWN ATOM OR ION 著者 Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2018-02-08 公開日 2018-03-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Nat. Chem. Biol., 14, 2018
8AEI	X-ray structure of Canis familiaris Odorant Binding Protein 2 bound to citronellal 分子名称: (3R)-3,7-dimethyloct-6-en-1-ol, MAGNESIUM ION, Minor allergen Can f 2 著者 Schwartz, M, Briand, L. 登録日 2022-07-13 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Structure of dog odorant binding protein To Be Published
6D0Y	X-ray Crystal Structure of PGC-1beta C-terminus bound to the CBP80-CBP20 Cap Binding Complex 分子名称: MAGNESIUM ION, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2, ... 著者 Gleghorn, M.L, Maquat, L.E. 登録日 2018-04-11 公開日 2018-04-25 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.676 Å) 主引用文献 Transcriptional coactivator PGC-1 alpha contains a novel CBP80-binding motif that orchestrates efficient target gene expression. Genes Dev., 32, 2018
6CE8	Crystal structure of fragment 2-(Benzo[d]thiazol-2-yl)acetic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain 分子名称: (1,3-benzothiazol-2-yl)acetic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ... 著者 Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Ravichandran, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC) 登録日 2018-02-11 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem., 61, 2018
6IOT	The ligand binding domain of Mlp24 with arginine 分子名称: ARGININE, CALCIUM ION, Methyl-accepting chemotaxis protein 著者 Takahashi, Y, Sumita, K, Nishiyama, S, Kawagishi, I, Imada, K. 登録日 2018-10-31 公開日 2019-03-20 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Calcium Ions Modulate Amino Acid Sensing of the Chemoreceptor Mlp24 ofVibrio cholerae. J. Bacteriol., 201, 2019
6CEC	Crystal structure of fragment 3-(3-Methoxy-2-quinoxalinyl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain 分子名称: 3-(3-methoxyquinoxalin-2-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ... 著者 Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Franzoni, I, Ravichandran, M, Lautens, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC) 登録日 2018-02-11 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem., 61, 2018
6IP7	Structure of human telomeric DNA with 5-Selenophene-modified deoxyuridine at residue 11 分子名称: DNA (22-MER), POTASSIUM ION 著者 Saikrishnan, K, Nuthanakanti, A, Srivatsan, S.G, Ahmad, I. 登録日 2018-11-02 公開日 2019-05-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Probing G-quadruplex topologies and recognition concurrently in real time and 3D using a dual-app nucleoside probe. Nucleic Acids Res., 47, 2019
6CEF	Crystal structure of fragment 3-(1,3-Benzothiazol-2-yl)propanoic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain 分子名称: 3-(1,3-benzothiazol-2-yl)propanoic acid, Histone deacetylase 6, UNKNOWN ATOM OR ION, ... 著者 Harding, R.J, Halabelian, L, Ferreira de Freitas, R, Ravichandran, M, Santhakumar, V, Schapira, M, Bountra, C, Edwards, A.M, Arrowsmith, C.M, Structural Genomics Consortium (SGC) 登録日 2018-02-11 公開日 2018-02-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem., 61, 2018
6D1N	Apo structure of Bacteroides uniformis Beta-glucuronidase 1 分子名称: Beta-galactosidase/beta-glucuronidase, CHLORIDE ION, GLYCEROL 著者 Walton, W.G, Pellock, S.J, Redinbo, M.R. 登録日 2018-04-12 公開日 2018-10-17 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Three structurally and functionally distinct beta-glucuronidases from the human gut microbeBacteroides uniformis. J. Biol. Chem., 293, 2018
6IC8	Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2 分子名称: PHD finger protein 3, TYR-SEP-PRO-THR-SER-PRO-SER-TYR-SEP-PRO-THR 著者 Grishkovskaya, I, Djinovic-Carugo, K, Slade, D. 登録日 2018-12-02 公開日 2020-07-15 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (1.929 Å) 主引用文献 PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC Nat Commun, 12, 2021
6IR1	Crystal structure of red fluorescent protein mCherry complexed with the nanobody LaM4 at 1.9 Angstron resolution 分子名称: MCherry fluorescent protein, mCherry's nanobody LaM4 著者 Ding, Y, Wang, Z.Y, Hu, R.T, Chen, X. 登録日 2018-11-09 公開日 2019-11-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.919 Å) 主引用文献 Structural insights into the binding of nanobodies LaM2 and LaM4 to the red fluorescent protein mCherry. Protein Sci., 30, 2021
6D3E	PPARg LBD in Complex with SR1988 分子名称: 1-[(2,4-difluorophenyl)methyl]-2,3-dimethyl-N-[(1R)-1-phenylpropyl]-1H-indole-5-carboxamide, Peroxisome proliferator-activated receptor gamma 著者 Frkic, R.L, Bruning, J.B. 登録日 2018-04-15 公開日 2019-02-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.395 Å) 主引用文献 Structural and Dynamic Elucidation of a Non-acid PPARgammaPartial Agonist: SR1988. Nucl Receptor Res, 5, 2018
6HTA	Crystal structure of glutathione transferase Xi 3 mutant C56S from Trametes versicolor 分子名称: ACETATE ION, DIMETHYL SULFOXIDE, Glutathione transferase Xi 3 C56S 著者 Schwartz, M, Favier, F, Didierjean, C. 登録日 2018-10-03 公開日 2018-10-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Trametes versicolor glutathione transferase Xi 3, a dual Cys-GST with catalytic specificities of both Xi and Omega classes. FEBS Lett., 592, 2018
6CC8	Crystal structure MBD3 MBD domain in complex with methylated CpG DNA 分子名称: Methyl-CpG-binding domain protein 3, UNKNOWN ATOM OR ION, methylated CpG DNA 著者 Liu, K, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2018-02-06 公開日 2018-04-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural analyses reveal that MBD3 is a methylated CG binder. Febs J., 286, 2019
6CCQ	Crystal structure of E.coli Phosphopantetheine Adenylyltransferase (PPAT/CoaD) in complex with 2-(3-chlorophenethyl)-1H-benzo[d]imidazol-4-ol 分子名称: 2-[2-(3-chlorophenyl)ethyl]-1H-benzimidazol-7-ol, Phosphopantetheine adenylyltransferase, SULFATE ION 著者 Mamo, M, Appleton, B.A. 登録日 2018-02-07 公開日 2018-03-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria. J. Med. Chem., 61, 2018
6HB5	Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-cytidine 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Tyrosine--tRNA ligase, ... 著者 De Graef, S, Pang, L, Strelkov, S.V, Weeks, S.D. 登録日 2018-08-09 公開日 2019-04-17 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases. Eur.J.Med.Chem., 173, 2019
6CD8	Complex of GID4 fragment with short peptide 分子名称: Glucose-induced degradation protein 4 homolog, Tetrapeptide PSRV, UNKNOWN ATOM OR ION 著者 Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2018-02-08 公開日 2018-03-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Nat. Chem. Biol., 14, 2018
6CDC	GID4 in complex with a tetrapeptide 分子名称: Glucose-induced degradation protein 4 homolog, Tetrapeptide PGLW, UNKNOWN ATOM OR ION 著者 Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2018-02-08 公開日 2018-03-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Nat. Chem. Biol., 14, 2018
6HUE	ParkinS65N 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ... 著者 McWilliams, T.G, Barini, E, Pohjolan-Pirhonen, R, Brooks, S.P, Singh, F, Burel, S, Balk, K, Kumar, A, Montava-Garriga, L, Prescott, A.R, Hassoun, S.M, Mouton-Liger, F, Ball, G, Hills, R, Knebel, A, Ulusoy, A, Di Monte, D.A, Tamjar, J, Antico, O, Fears, K, Smith, L, Brambilla, R, Palin, E, Valori, M, Eerola-Rautio, J, Tienari, P, Corti, O, Dunnett, S.B, Ganley, I.G, Suomalainen, A, Muqit, M.M.K. 登録日 2018-10-07 公開日 2018-10-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Phosphorylation of Parkin at serine 65 is essential for its activation in vivo . Open Biology, 8, 2018
6HEH	Structure of the catalytic domain of USP28 (insertion deleted) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28 著者 Gersch, M, Komander, D. 登録日 2018-08-20 公開日 2019-03-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity. Mol.Cell, 74, 2019
6HEI	Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA 分子名称: 1,2-ETHANEDIOL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28 著者 Gersch, M, Komander, D. 登録日 2018-08-20 公開日 2019-03-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity. Mol.Cell, 74, 2019
6CEY	Aminoglycoside Phosphotransferase (2'')-Ia in complex with GMPPNP, Magnesium, and Lividomycin moieties 分子名称: (2R,3S,4S,5S,6R)-2-((2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3S,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R ,5S,6R)-3-AMINO-5-HYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-4-HYDROXY-2-(HYDROXYMET HYL)-TETRAHYDROFURAN-3-YLOXY)-4-HYDROXY-TETRAHYDRO-2H-PYRAN-3-YLOXY)-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL, Bifunctional AAC/APH, CHLORIDE ION, ... 著者 Caldwell, S.J, Berghuis, A.M. 登録日 2018-02-13 公開日 2018-04-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Plasticity of Aminoglycoside Binding to Antibiotic Kinase APH(2′′)-Ia. Antimicrob. Agents Chemother., 62, 2018
6HEU	Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative AT058 分子名称: 3-[(4,6-dipyridin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide, Ephrin type-A receptor 2 著者 Kudlinzki, D, Troester, A, Witt, K, Linhard, V.L, Gande, S.L, Saxena, K, Schwalbe, H. 登録日 2018-08-20 公開日 2019-08-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.719 Å) 主引用文献 Effects of NVP-BHG712 chemical modifications on EPHA2 binding and affinity To Be Published
6HFJ	Human dihydroorotase mutant F1563A co-crystallized with carbamoyl aspartate at pH 7.5 分子名称: (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, CAD protein, FORMIC ACID, ... 著者 Ramon-Maiques, S, Grande Garcia, A. 登録日 2018-08-21 公開日 2018-10-24 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD. J. Biol. Chem., 293, 2018

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