6HEU

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with the NVP-BHG712 derivative AT058

Summary for 6HEU

• Entry DOI: 10.2210/pdb6heu/pdb
• Descriptor: Ephrin type-A receptor 2, 3-[(4,6-dipyridin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{N}-[3-(trifluoromethyl)phenyl]benzamide (3 entities in total)
• Functional Keywords: inhibitor, complex, protein tyrosine kinase, transferase
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 34990.34

Authors

Kudlinzki, D.,Troester, A.,Witt, K.,Linhard, V.L.,Gande, S.L.,Saxena, K.,Schwalbe, H. (deposition date: 2018-08-20, release date: 2019-08-28, Last modification date: 2024-01-17)

• Primary citation: Troester, A.,Kudlinzki, D.,Saxena, K.,Gande, S.,Schwalbe, H.; Effects of NVP-BHG712 chemical modifications on EPHA2 binding and affinity; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.719 Å)