PPARg LBD in Complex with SR1988

Summary for 6D3E

DescriptorPeroxisome proliferator-activated receptor gamma, 1-[(2,4-difluorophenyl)methyl]-2,3-dimethyl-N-[(1R)-1-phenylpropyl]-1H-indole-5-carboxamide (3 entities in total)
Functional Keywordstype 2 diabetes, nuclear receptor, drug discovery, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight64584.88
Frkic, R.L.,Bruning, J.B. (deposition date: 2018-04-15, release date: 2019-02-27, Last modification date: 2019-04-10)
Primary citation
Frkic, R.L.,Chua, B.S.,Shin, Y.,Pascal, B.D.,Novick, S.J.,Kamenecka, T.M.,Griffin, P.R.,Bruning, J.B.
Structural and Dynamic Elucidation of a Non-acid PPARgammaPartial Agonist: SR1988.
Nucl Receptor Res, 5:-, 2018
PubMed: 30906767 (PDB entries with the same primary citation)
DOI: 10.11131/2018/101350
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2643 0.2% 1.7% 8.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-07-29