6IC8

Crystal structure of the SPOC domain of human PHF3 in complex with RNA polymerase II CTD diheptapeptide phosphorylated on Ser2

Summary for 6IC8

Entry DOI	10.2210/pdb6ic8/pdb
Descriptor	PHD finger protein 3, TYR-SEP-PRO-THR-SER-PRO-SER-TYR-SEP-PRO-THR (3 entities in total)
Functional Keywords	spoc domain, phf3, pser2 peptide, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	39657.21
Authors	Grishkovskaya, I.,Djinovic-Carugo, K.,Slade, D. (deposition date: 2018-12-02, release date: 2020-07-15, Last modification date: 2024-11-13)
Primary citation	Appel, L.M.,Franke, V.,Bruno, M.,Grishkovskaya, I.,Kasiliauskaite, A.,Kaufmann, T.,Schoeberl, U.E.,Puchinger, M.G.,Kostrhon, S.,Ebenwaldner, C.,Sebesta, M.,Beltzung, E.,Mechtler, K.,Lin, G.,Vlasova, A.,Leeb, M.,Pavri, R.,Stark, A.,Akalin, A.,Stefl, R.,Bernecky, C.,Djinovic-Carugo, K.,Slade, D. PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC Nat Commun, 12:6078-, 2021 Cited by DOI: 10.1038/s41467-021-26360-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.929 Å)

Structure validation