6CE8

Crystal structure of fragment 2-(Benzo[d]thiazol-2-yl)acetic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

Summary for 6CE8

Entry DOI	10.2210/pdb6ce8/pdb
Descriptor	Histone deacetylase 6, ZINC ION, UNKNOWN ATOM OR ION, ... (5 entities in total)
Functional Keywords	histone deacetylase, hdac, hdac6, ubiquitin, structural genomics consortium, sgc, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: Q9UBN7
Total number of polymer chains	1
Total formula weight	12322.06
Authors	Harding, R.J.,Halabelian, L.,Ferreira de Freitas, R.,Ravichandran, M.,Santhakumar, V.,Schapira, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.M.,Structural Genomics Consortium (SGC) (deposition date: 2018-02-11, release date: 2018-02-28, Last modification date: 2023-10-04)
Primary citation	Ferreira de Freitas, R.,Harding, R.J.,Franzoni, I.,Ravichandran, M.,Mann, M.K.,Ouyang, H.,Lautens, M.,Santhakumar, V.,Arrowsmith, C.H.,Schapira, M. Identification and Structure-Activity Relationship of HDAC6 Zinc-Finger Ubiquitin Binding Domain Inhibitors. J. Med. Chem., 61:4517-4527, 2018 Cited by PubMed: 29741882 DOI: 10.1021/acs.jmedchem.8b00258 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation