6CE8

Crystal structure of fragment 2-(Benzo[d]thiazol-2-yl)acetic acid bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1301

Chain	Residue
A	CYS1145
A	CYS1148
A	HIS1164
A	HIS1170

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1302

Chain	Residue
A	CYS1133
A	CYS1136
A	CYS1153
A	HIS1160

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1303

Chain	Residue
A	HIS1115
A	CYS1183
A	CYS1186
A	CYS1113

---

site_id	AC4
Number of Residues	8
Details	binding site for residue EYV A 1308

Chain	Residue
A	TRP1143
A	GLY1154
A	ARG1155
A	TRP1182
A	TYR1184
A	TYR1189
A	HOH1417
A	HOH1431

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Region: {"description":"Ubiquitin binding","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of human HDAC6 zinc finger domain.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

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