PDB: 224004 件ウェブページステータス検索Chemie searchBIRD

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7Q24	Crystal structure of Angiotensin-1 converting enzyme N-domain in complex with dual ACE/NEP inhibitor AD011 分子名称: (2~{S})-2-[[(2~{S})-1-[[(2~{S})-3-(1~{H}-indol-3-yl)-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-hexan-2-yl]amino]-4-phenyl-butanoic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Cozier, G.E, Acharya, K.R. 登録日 2021-10-23 公開日 2022-02-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. J.Med.Chem., 65, 2022
7Q25	Crystal structure of Angiotensin-1 converting enzyme N-domain in complex with dual ACE/NEP inhibitor AD012 分子名称: (2~{S})-2-[[(2~{S})-1-[[(2~{S})-3-(4-hydroxyphenyl)-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-hexan-2-yl]amino]-4-phenyl-butanoic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Cozier, G.E, Acharya, K.R. 登録日 2021-10-23 公開日 2022-02-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition. J.Med.Chem., 65, 2022
6EAA	X-ray crystal structure of Pf-M1 in complex with inhibitor (6i) and catalytic zinc ion 分子名称: GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... 著者 Drinkwater, N, McGowan, S. 登録日 2018-08-02 公開日 2018-12-26 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases. J. Med. Chem., 62, 2019
6O56	HNH Nuclease from S. pyogenes Cas9 分子名称: CRISPR-associated endonuclease Cas9/Csn1 著者 Newton, J.C, Lisi, G.P, Jogl, G. 登録日 2019-03-01 公開日 2020-01-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics. J.Am.Chem.Soc., 142, 2020
7NP1	Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-360 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoblobulin light chain, Immunoglobulin gamma-1 heavy chain, ... 著者 Hall, G, Cowan, R, Carr, M. 登録日 2021-02-26 公開日 2021-11-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses. Front Immunol, 12, 2021
6KTZ	The complex structure of EanB/C412S with hercynine 分子名称: 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ... 著者 Wu, L, Liu, P.H, Zhou, J.H. 登録日 2019-08-29 公開日 2020-08-26 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis Acs Catalysis, 10, 2020
7YS8	Crystal Structure of UDP-glucose 4-epimerase (Rv3634c) from Mycobacterium tuberculosis 分子名称: ACETATE ION, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Yadav, S, Bhatia, I, Biswal, B.K. 登録日 2022-08-11 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Crystal Structure of UDP-glucose 4-epimerase (Rv3634c) from Mycobacterium tuberculosis To Be Published
6KU3	Crystal structure of gibberellin 2-oxidase3 (GA2ox3)in rice 分子名称: 2-OXOGLUTARIC ACID, GIBBERELLIN A4, GLYCEROL, ... 著者 Takehara, S, Mikami, B, Sakuraba, S, Matsuoka, M, Ueguchi-Tanaka, M. 登録日 2019-08-30 公開日 2020-05-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A common allosteric mechanism regulates homeostatic inactivation of auxin and gibberellin. Nat Commun, 11, 2020
4UDS	Crystal structure of MbdR regulator from Azoarcus sp. CIB 分子名称: MBDR REGULATOR 著者 Liu, H, Liu, H.X, MacMahon, S.A, Juarez, J.F, Zamarro, M.T, Eberlein, C, Boll, M, Carmona, M, Diaz, E, Naismith, J.H. 登録日 2014-12-11 公開日 2014-12-24 最終更新日 2017-09-13 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Unraveling the Specific Regulation of the Mbd Central Pathway for the Anaerobic Degradation of 3-Methylbenzoate. J.Biol.Chem., 290, 2015
1ISG	Crystal Structure Analysis of BST-1/CD157 with ATPgammaS 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, bone marrow stromal cell antigen 1 著者 Yamamoto-Katayama, S, Ariyoshi, M, Ishihara, K, Hirano, T, Jingami, H, Morikawa, K. 登録日 2001-12-05 公開日 2002-03-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. J.Mol.Biol., 316, 2002
6LKG	two-component system protein mediate signal transduction 分子名称: 6-O-phosphono-alpha-D-glucopyranose, ABC transporter, solute-binding protein, ... 著者 Wang, M, Tao, Y. 登録日 2019-12-19 公開日 2020-12-02 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.948 Å) 主引用文献 Interface switch mediates signal transmission in a two-component system. Proc.Natl.Acad.Sci.USA, 117, 2020
4WIF	Crystal structure of E47Q mutant cytidine deaminase from Mycobacterium tuberculosis (MtCDA E47Q) 分子名称: Cytidine deaminase, ZINC ION 著者 Trivella, D.B, Sanchez-Quitian, A.Z, Basso, L.A, Santos, D.S. 登録日 2014-09-25 公開日 2015-09-09 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of E47Q mutant cytidine deaminase from Mycobacterium tuberculosis (MtCDA E47Q) Rsc Adv, 2015
7YPZ	Zafirlukast in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... 著者 Sun, Q, Lei, Y. 登録日 2022-08-05 公開日 2023-08-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach. J.Med.Chem., 66, 2023
8ESV	Structure of human ADAM10-Tspan15 complex bound to 11G2 vFab 分子名称: 11G2 Fab Heavy Chain, 11G2 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lipper, C.H, Blacklow, S.C. 登録日 2022-10-14 公開日 2023-06-14 最終更新日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for membrane-proximal proteolysis of substrates by ADAM10. Cell, 186, 2023
6OMK	Crystal structure of a glycylpeptide N-tetradecanoyltransferase (N-myristoyl transferase, NMT) from Leishmania major Friedlin bound to tetradecanoyl-CoA 分子名称: 1,2-ETHANEDIOL, Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2019-04-18 公開日 2019-05-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of a glycylpeptide N-tetradecanoyltransferase (N-myristoyl transferase, NMT) from Leishmania major Friedlin bound to tetradecanoyl-CoA To Be Published
6KVY	The structure of EanB/T414A complex with hercynine 分子名称: CHLORIDE ION, MAGNESIUM ION, N,N,N-trimethyl-histidine, ... 著者 Wu, L, Liu, P.H, Zhou, J.H. 登録日 2019-09-05 公開日 2020-09-09 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 The structure of EanB/T414A complex with hercynine To Be Published
5E9U	Crystal structure of GtfA/B complex bound to UDP and GlcNAc 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycosyltransferase Gtf1, Glycosyltransferase-stabilizing protein Gtf2, ... 著者 Chen, Y, Rapoport, T.A. 登録日 2015-10-15 公開日 2016-03-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.84 Å) 主引用文献 Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Proc.Natl.Acad.Sci.USA, 113, 2016
6OMQ	Crystal structure of PtmU3 complexed with PTM substrate 分子名称: ACETATE ION, MANGANESE (II) ION, PtmU3, ... 著者 Liu, Y.C, Dong, L.B, Shen, B. 登録日 2019-04-19 公開日 2019-07-24 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. J.Am.Chem.Soc., 141, 2019
7PXP	Benzoylsuccinyl-CoA thiolase 分子名称: Benzoylsuccinyl-CoA thiolase subunit, ZINC ION 著者 Ermler, U, Heider, H, Weidenweber, S, Demmer, U. 登録日 2021-10-08 公開日 2022-04-06 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism. Febs J., 289, 2022
2RHP	The Thrombospondin-1 Polymorphism Asn700Ser Associated with Cornoary Artery Disease Causes Local and Long-Ranging Changes in Protein Structure 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Carlson, C.B, Keck, J.L, Mosher, D.F. 登録日 2007-10-09 公開日 2008-05-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Influences of the N700S Thrombospondin-1 Polymorphism on Protein Structure and Stability. J.Biol.Chem., 283, 2008
4HJZ	1.9 A Crystal structure of E. coli MltE-E64Q with bound chitopentaose 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 Fibriansah, G, Gliubich, F.I, Thunnissen, A.-M.W.H. 登録日 2012-10-14 公開日 2012-10-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 On the Mechanism of Peptidoglycan Binding and Cleavage by the endo-Specific Lytic Transglycosylase MltE from Escherichia coli. Biochemistry, 51, 2012
6KZW	Crystal structure of YggS family pyridoxal phosphate-dependent enzyme PipY from Fusobacterium nucleatum 分子名称: PHOSPHATE ION, Pyridoxal phosphate homeostasis protein 著者 Chen, Y, Wang, L, Shang, F, Lan, J, Liu, W, Xu, Y. 登録日 2019-09-25 公開日 2019-10-16 最終更新日 2021-01-13 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Crystal structure of YggS family pyridoxal phosphate-dependent enzyme PipY from Fusobacterium nucleatum To Be Published
2RJQ	Crystal structure of ADAMTS5 with inhibitor bound 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, ADAMTS-5, ... 著者 Mosyak, L, Stahl, M, Somers, W. 登録日 2007-10-15 公開日 2007-12-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci., 17, 2008
6OB2	Crystal structure of wild-type KRAS (GMPPNP-bound) in complex with GAP-related domain (GRD) of neurofibromin (NF1) 分子名称: CHLORIDE ION, GLYCEROL, GTPase KRas, ... 著者 Tran, T.H, Dharmaiah, S, Simanshu, D.K. 登録日 2019-03-19 公開日 2019-10-16 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.845 Å) 主引用文献 KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. Proc.Natl.Acad.Sci.USA, 116, 2019
6L3T	Human Cx31.3/GJC3 connexin hemichannel in the absence of calcium 分子名称: Gap junction gamma-3 protein, Lauryl Maltose Neopentyl Glycol 著者 Lee, H.J, Jeong, H, Ryu, B, Hyun, J, Woo, J.S. 登録日 2019-10-15 公開日 2020-09-09 最終更新日 2020-10-14 実験手法 ELECTRON MICROSCOPY (2.34 Å) 主引用文献 Cryo-EM structure of human Cx31.3/GJC3 connexin hemichannel. Sci Adv, 6, 2020

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