PDB: 47065 件ウェブページステータス検索Chemie searchBIRD

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6CWG	Ricin catalytic subunit bound go A9 VHH antibody 分子名称: CHLORIDE ION, Ricin, VHH antibody 著者 Rudolph, M.J, Mantis, N. 登録日 2018-03-30 公開日 2019-01-16 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity. Protein Eng. Des. Sel., 31, 2018
6CXJ	Cardiac thin filament decorated with C0C1 fragment of cardiac myosin binding protein C mode 2 分子名称: Actin, cytoplasmic 2, Myosin-binding protein C, ... 著者 Galkin, V.E, Schroeder, G.F. 登録日 2018-04-03 公開日 2018-10-10 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (11 Å) 主引用文献 N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament. Structure, 26, 2018
6CXY	Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody Fab mAb-1_19A11 分子名称: 1,2-ETHANEDIOL, CALCIUM ION, Cadherin-1, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2018-04-04 公開日 2019-04-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody Fab mAb-1_19A11 to be published
2R43	I50V HIV-1 protease in complex with an amino decorated pyrrolidine-based inhibitor 分子名称: CHLORIDE ION, GLYCEROL, N,N'-(3S,4S)-PYRROLIDINE-3,4-DIYLBIS(4-AMINO-N-BENZYLBENZENESULFONAMIDE), ... 著者 Boettcher, J, Blum, A, Heine, A, Diederich, W.E, Klebe, G. 登録日 2007-08-30 公開日 2008-09-09 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structural and Kinetic Analysis of Pyrrolidine-Based Inhibitors of the Drug-Resistant Ile84Val Mutant of HIV-1 Protease J.Mol.Biol., 383, 2008
6D0J	Crystal structure of a CLC-type fluoride/proton antiporter 分子名称: (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, CLC-type fluoride/proton antiporter, DECYL-BETA-D-MALTOPYRANOSIDE, ... 著者 Last, N.B, Stockbridge, R.B, Wilson, A.E, Shane, T, Kolmakova-Partensky, L, Koide, A, Koide, S, Miller, C. 登録日 2018-04-10 公開日 2018-07-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A CLC-type F-/H+antiporter in ion-swapped conformations. Nat. Struct. Mol. Biol., 25, 2018
6CUB	Structure of human DNA polymerase beta complexed with 8-ClG in the template base paired with incoming non-hydrolyzable ATP and MANGANESE 分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*CP*GP*AP*CP*(CGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... 著者 Koag, M.-C, Lee, S. 登録日 2018-03-25 公開日 2019-03-27 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure of human DNA polymerase beta complexed with 8-ClG in the template base paired with incoming non-hydrolyzable ATP and MANGANESE To Be Published
6CUK	Engineered Cytochrome c from Rhodothermus marinus, Rma TDE 分子名称: Cytochrome c, HEME C 著者 Lewis, R.D, Buller, A.R, Arnold, F.H. 登録日 2018-03-26 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Catalytic iron-carbene intermediate revealed in a cytochromeccarbene transferase. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CVM	Atomic resolution cryo-EM structure of beta-galactosidase 分子名称: 2-phenylethyl 1-thio-beta-D-galactopyranoside, Beta-galactosidase, MAGNESIUM ION, ... 著者 Subramaniam, S, Bartesaghi, A, Banerjee, S, Zhu, X, Milne, J.L.S. 登録日 2018-03-28 公開日 2018-05-30 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (1.9 Å) 主引用文献 Atomic Resolution Cryo-EM Structure of beta-Galactosidase. Structure, 26, 2018
2QP3	Identification and Characterization of Two Amino Acids Critical for the Substrate Inhibition of SULT2A1 分子名称: (3Beta,5alpha)-3-Hydroxyandrostan-17-one, Bile salt sulfotransferase 著者 Hsieh, Y.C. 登録日 2007-07-23 公開日 2008-07-29 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Identification and characterization of two amino acids critical for the substrate inhibition of human dehydroepiandrosterone sulfotransferase (SULT2A1) Mol.Pharmacol., 73, 2008
6CUV	Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6 分子名称: PHOSPHATE ION, SODIUM ION, Tryptophan synthase beta chain 1 著者 Scheele, R.A, Buller, A.R, Boville, C.E, Arnold, F.H. 登録日 2018-03-26 公開日 2018-09-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues. Angew. Chem. Int. Ed. Engl., 57, 2018
2QHX	Structure of Pteridine Reductase from Leishmania major complexed with a ligand 分子名称: IODIDE ION, METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL](METHYL)AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Gibellini, F, Mcluskey, K, Tulloch, L, Hunter, W.N. 登録日 2007-07-03 公開日 2007-12-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. Proc.Natl.Acad.Sci.USA, 105, 2008
6D0O	rdpA dioxygenase holoenzyme 分子名称: (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase, 2-OXOGLUTARIC ACID, COBALT (II) ION 著者 Rydel, T.J, Sturman, E.J, Zheng, M, Evdokimov, A. 登録日 2018-04-10 公開日 2018-08-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Development of enzymes for robust aryloxyphenoxypropionate and synthetic auxin herbicide tolerance traits in maize and soybean crops. Pest Manag. Sci., 75, 2019
5VKJ	Crystal structure of human CD22 Ig domains 1-3 分子名称: B-cell receptor CD22, GLYCEROL, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Julien, J.P, Ereno-Orbea, J, Sicard, T. 登録日 2017-04-21 公開日 2017-10-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Molecular basis of human CD22 function and therapeutic targeting. Nat Commun, 8, 2017
6CXD	Crystal structure of peptidase B from Yersinia pestis CO92 at 2.75 A resolution 分子名称: Peptidase B, SULFATE ION 著者 Woinska, M, Lipowska, J, Shabalin, I.G, Cymborowski, M, Grimshaw, S, Winsor, J, Shuvalova, L, Satchell, K.J, Joachimiak, A, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2018-04-02 公開日 2018-04-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain. Febs J., 287, 2020
6CYO	Crystal structure of human UBE2A (RAD6A) 分子名称: Ubiquitin-conjugating enzyme E2 A 著者 Ranzani, A.T, de Oliveira, J.F. 登録日 2018-04-06 公開日 2018-12-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability. Nat. Chem. Biol., 15, 2019
2QSG	Crystal structure of Rad4-Rad23 bound to a UV-damaged DNA 分子名称: DNA repair protein RAD4, UV excision repair protein RAD23, damaged strand of the CPD-mismatch DNA, ... 著者 Min, J.-H, Pavletich, N.P. 登録日 2007-07-31 公開日 2007-10-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Recognition of DNA damage by the Rad4 nucleotide excision repair protein Nature, 449, 2007
5VY8	S. cerevisiae Hsp104-ADP complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 104 著者 Gates, S.N, Yokom, A.L, Lin, J.-B, Jackrel, M.E, Rizo, A.N, Kendsersky, N.M, Buell, C.E, Sweeny, E.A, Chuang, E, Torrente, M.P, Mack, K.L, Su, M, Shorter, J, Southworth, D.R. 登録日 2017-05-24 公開日 2017-07-05 最終更新日 2018-08-15 実験手法 ELECTRON MICROSCOPY (5.6 Å) 主引用文献 Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science, 357, 2017
6CY9	SA11 Rotavirus NSP2 with disulfide bridge 分子名称: MAGNESIUM ION, Non-structural protein 2 著者 Anish, R, Hu, L, Sankaran, B, Prasad, B.V.V. 登録日 2018-04-05 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.615 Å) 主引用文献 Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CZF	The structure of E. coli PurF in complex with ppGpp-Mg 分子名称: Amidophosphoribosyltransferase, GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION 著者 Wang, B, Grant, R.A, Laub, M.T. 登録日 2018-04-09 公開日 2018-10-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Affinity-based capture and identification of protein effectors of the growth regulator ppGpp. Nat. Chem. Biol., 15, 2019
5VZF	Post-catalytic complex of human Polymerase Mu (W434A) mutant with incoming dTTP 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*GP*CP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ... 著者 Moon, A.F, Pryor, J.M, Ramsden, D.A, Kunkel, T.A, Bebenek, K, Pedersen, L.C. 登録日 2017-05-27 公開日 2017-07-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Nucleic Acids Res., 45, 2017
2OPH	Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor 分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Scapin, G, Weber, A.E, Duffy, J.L. 登録日 2007-01-29 公開日 2007-05-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV. Bioorg.Med.Chem.Lett., 17, 2007
5W1G	CR1-07 unliganded Fab 分子名称: CR1-07 Fab heavy chain, CR1-07 Fab light chain 著者 Raymond, D.D, Clark, L.E, Abraham, J. 登録日 2017-06-03 公開日 2018-05-30 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. Nat Commun, 9, 2018
2ON6	Crystal structure of human purine nucleoside phosphorylase mutant H257F with Imm-H 分子名称: 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, Purine nucleoside phosphorylase 著者 Rinaldo-Matthis, A, Murkin, A.S, Almo, S.C, Schramm, V.L. 登録日 2007-01-23 公開日 2007-05-22 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.503 Å) 主引用文献 Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase Biochemistry, 46, 2007
5VD0	CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN IN COMPLEX WITH MK1775 分子名称: 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, DI(HYDROXYETHYL)ETHER, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 著者 Zhu, J.-Y, Schonbrunn, E. 登録日 2017-04-01 公開日 2017-08-23 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J. Med. Chem., 60, 2017
2ONC	Crystal structure of human DPP-4 分子名称: 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Feng, J, Zhang, Z, Wallace, M.B, Stafford, J.A, Kaldor, S.W, Kassel, D.B, Navre, M, Shi, L, Skene, R.J, Asakawa, T, Takeuchi, K, Xu, R, Webb, D.R, Gwaltney, S.L. 登録日 2007-01-23 公開日 2008-03-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J.Med.Chem., 50, 2007

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