2ONC

Crystal structure of human DPP-4

Summary for 2ONC

Entry DOI	10.2210/pdb2onc/pdb
Descriptor	Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	dpp4 protein-inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	346989.81
Authors	Feng, J.,Zhang, Z.,Wallace, M.B.,Stafford, J.A.,Kaldor, S.W.,Kassel, D.B.,Navre, M.,Shi, L.,Skene, R.J.,Asakawa, T.,Takeuchi, K.,Xu, R.,Webb, D.R.,Gwaltney, S.L. (deposition date: 2007-01-23, release date: 2008-03-04, Last modification date: 2023-12-27)
Primary citation	Feng, J.,Zhang, Z.,Wallace, M.B.,Stafford, J.A.,Kaldor, S.W.,Kassel, D.B.,Navre, M.,Shi, L.,Skene, R.J.,Asakawa, T.,Takeuchi, K.,Xu, R.,Webb, D.R.,Gwaltney, S.L. Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J.Med.Chem., 50:2297-2300, 2007 Cited by PubMed: 17441705 DOI: 10.1021/jm070104l PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation