2ONC
Crystal structure of human DPP-4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dipeptidyl peptidase 4 | polymer | 731 | 84723.9 | 4 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (human) | Dipeptidyl peptidase, DPP IV, T-cell activation antigen CD26, TP103, Adenosine deaminase complexing protein 2, ADABP |
| 2 | E, F, G, H, I (E, F, G, H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 3 | BA, CA, J, K, L... (D, A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 14 | Chemie (NAG) | |||
| 4 | AA, DA, EA, N, O... (C, D, A, B) | 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE | non-polymer | 359.4 | 8 | Chemie (SY1) | |||
| 5 | FA, GA, HA, IA (A, B, C, D) | water | water | 18.0 | 756 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 41 - 766 (UniProt: P27487)
| PDB | External Database | Details |
|---|---|---|
| His 36 | - | expression tag |
| His 37 | - | expression tag |
| Ala 38 | - | expression tag |
| Ser 39 | - | expression tag |
| Ala 40 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 338895.5 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2122.0 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 5972.3 | |
| All* | Total formula weight | 346989.8 |
