2QHX

Structure of Pteridine Reductase from Leishmania major complexed with a ligand

Summary for 2QHX

Entry DOI	10.2210/pdb2qhx/pdb
Related	1E92 1W0C 2ATD 2BFA 2BFM 2BFP
Descriptor	Pteridine reductase 1, IODIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	oxidoreductase, short-chain dehydrogenase/reductase, pteridine reductase, trypanosomatid, pterin salvage, drug resistance, methotrexate resistance, enzyme inhibitor, nadp/nadph
Biological source	Leishmania major
Total number of polymer chains	4
Total formula weight	144162.51
Authors	Gibellini, F.,Mcluskey, K.,Tulloch, L.,Hunter, W.N. (deposition date: 2007-07-03, release date: 2007-12-25, Last modification date: 2024-02-21)
Primary citation	Cavazzuti, A.,Paglietti, G.,Hunter, W.N.,Gamarro, F.,Piras, S.,Loriga, M.,Allecca, S.,Corona, P.,McLuskey, K.,Tulloch, L.,Gibellini, F.,Ferrari, S.,Costi, M.P. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. Proc.Natl.Acad.Sci.USA, 105:1448-1453, 2008 Cited by PubMed: 18245389 DOI: 10.1073/pnas.0704384105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation