2BFA

Leishmania major pteridine reductase 1 in complex with NADP and CB3717

Summary for 2BFA

Entry DOI	10.2210/pdb2bfa/pdb
Related	1E7W 1E92 1W0C 2BF7 2BFM 2BFO 2BFP
Descriptor	PTERIDINE REDUCTASE 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (5 entities in total)
Functional Keywords	pteridine reductase, trypanosomatids, drug resistance, pterin salvage, short-chain dehydrogenase/reductase, methotrexate resistance, nadp, oxidoreductase
Biological source	LEISHMANIA MAJOR
Total number of polymer chains	4
Total formula weight	127026.29
Authors	Schuettelkopf, A.W.,Hunter, W.N. (deposition date: 2004-12-06, release date: 2005-08-31, Last modification date: 2023-12-13)
Primary citation	Schuettelkopf, A.W.,Hardy, L.W.,Beverley, S.M.,Hunter, W.N. Structures of Leishmania Major Pteridine Reductase Complexes Reveal the Active Site Features Important for Ligand Binding and to Guide Inhibitor Design J.Mol.Biol., 352:105-, 2005 Cited by PubMed: 16055151 DOI: 10.1016/J.JMB.2005.06.076 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation