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1E92

Pteridine reductase 1 from Leishmania major complexed with NADP+ and dihydrobiopterin

Summary for 1E92
Entry DOI10.2210/pdb1e92/pdb
Related1E7W
DescriptorPTERIDINE REDUCTASE 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 7,8-DIHYDROBIOPTERIN, ... (5 entities in total)
Functional Keywordspteridine reductase, trypanosomatids, drug resistance, pterin salvage, short-chain dehydrogenase/reductase
Biological sourceLEISHMANIA MAJOR
Total number of polymer chains4
Total formula weight125941.14
Authors
Schuettelkopf, A.W.,Hunter, W.N. (deposition date: 2000-10-04, release date: 2001-10-05, Last modification date: 2023-12-13)
Primary citationGourley, D.G.,Schuettelkopf, A.W.,Leonard, G.A.,Luba, J.,Hardy, L.W.,Beverley, S.M.,Hunter, W.N.
Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites
Nat.Struct.Biol., 8:521-, 2001
Cited by
PubMed: 11373620
DOI: 10.1038/88584
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

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