2QHX
Structure of Pteridine Reductase from Leishmania major complexed with a ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Pteridine reductase 1 | polymer | 328 | 34783.3 | 4 | UniProt (Q01782) Pfam (PF13561) | Leishmania major | H region methotrexate resistance protein |
| 2 | E, H (A, B) | IODIDE ION | non-polymer | 126.9 | 2 | Chemie (IOD) | |||
| 3 | F, I, K, M (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 4 | G, J, L, N (A, B, C, D) | METHYL 1-(4-{[(2,4-DIAMINOPTERIDIN-6-YL)METHYL](METHYL)AMINO}BENZOYL)PIPERIDINE-4-CARBOXYLATE | non-polymer | 450.5 | 4 | Chemie (FE1) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 806 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 288 (UniProt: Q01782)
| PDB | External Database | Details |
|---|---|---|
| Met -39 | - | expression tag |
| Gly -38 | - | expression tag |
| Ser -37 | - | expression tag |
| Ser -36 | - | expression tag |
| His -35 | - | expression tag |
| His -34 | - | expression tag |
| His -33 | - | expression tag |
| His -32 | - | expression tag |
| His -31 | - | expression tag |
| His -30 | - | expression tag |
| Ser -29 | - | expression tag |
| Ser -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Leu -26 | - | expression tag |
| Val -25 | - | expression tag |
| Pro -24 | - | expression tag |
| Arg -23 | - | expression tag |
| Gly -22 | - | expression tag |
| Ser -21 | - | expression tag |
| His -20 | - | expression tag |
| Met -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Ser -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Val 162 | Phe 162 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 139133.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 5029.4 | |
| All* | Total formula weight | 144162.5 |
