PDB: 377 件ウェブページステータス検索Chemie searchBIRD

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4FBK	Crystal structure of a covalently fused Nbs1-Mre11 complex with one manganese ion per active site 分子名称: DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN, MANGANESE (II) ION, SULFATE ION 著者 Schiller, C.B, Lammens, K, Hopfner, K.P. 登録日 2012-05-23 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.379 Å) 主引用文献 Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling. Nat.Struct.Mol.Biol., 19, 2012
8SW5	Protein Phosphatase 1 in complex with PP1-specific Phosphatase targeting peptide (PhosTAP) version 1 分子名称: MANGANESE (II) ION, PHOSPHATE ION, PP1-specific Phosphatase-Targeting Peptide version 1, ... 著者 Choy, M.S, Peti, W, Page, R. 登録日 2023-05-17 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 A Protein Phosphatase 1 specific phosphatase targeting peptide (PhosTAP) to identify the PP1 phosphatome To Be Published
5JPF	Serine/Threonine phosphatase Z1 (Candida albicans) binds to inhibitor microcystin-LR 分子名称: MALONATE ION, MANGANESE (II) ION, Microcystin-LR, ... 著者 Choy, M.S, Chen, E.H, Peti, W, Page, R. 登録日 2016-05-03 公開日 2016-08-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.39929724 Å) 主引用文献 Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans. Mbio, 7, 2016
1S3L	Structural and Functional Characterization of a Novel Archaeal Phosphodiesterase 分子名称: Hypothetical protein MJ0936, PHOSPHATE ION, UNKNOWN ATOM OR ION 著者 Chen, S, Busso, D, Yakunin, A.F, Kuznetsova, E, Proudfoot, M, Jancrick, J, Kim, R, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) 登録日 2004-01-13 公開日 2004-08-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii J.Biol.Chem., 279, 2004
6G46	Red kidney bean purple acid phosphatase in complex with 2-(Naphthalen-1-yl)thiazole-4-carboxylic acid 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-naphthalen-1-yl-1,3-thiazole-4-carboxylic acid, ... 著者 Feder, D.F. 登録日 2018-03-26 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics. Eur J Med Chem, 157, 2018
4O43	DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities 分子名称: (5~{E})-3-[(2~{R})-butan-2-yl]-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, Exonuclease, putative, ... 著者 Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A. 登録日 2013-12-18 公開日 2014-01-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. Mol.Cell, 53, 2014
1XM7	The Crystal Structure of the Protein of Unknown Function AQ665 from Aquifex aeolicus 分子名称: hypothetical protein aq_1665 著者 Zhang, R, Zhou, M, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2004-10-01 公開日 2004-11-16 最終更新日 2012-09-26 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The crystal structure of the hypothetical protein aq_1665 from Aquifex aeolicus To be Published
2ZOA	Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) COLLECTED AT 1.280 ANGSTROM 分子名称: FE (II) ION, MALONATE ION, Phosphohydrolase 著者 Ollis, D.L, Jackson, C.J, Carr, P.D. 登録日 2008-05-07 公開日 2008-10-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Malonate-bound structure of the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) and characterization of the native Fe2+ metal-ion preference. Acta Crystallogr.,Sect.F, 64, 2008
2QFR	Crystal structure of red kidney bean purple acid phosphatase with bound sulfate 分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, ... 著者 Guddat, L.W, Schenk, G, Gahan, L.R, Elliot, T.W, Leung, E. 登録日 2007-06-27 公開日 2008-10-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. Bmc Struct.Biol., 8, 2008
4I5L	Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, MALONATE ION, ... 著者 Wlodarchak, N, Satyshur, K.A, Guo, F, Xing, Y. 登録日 2012-11-28 公開日 2013-05-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Structure of the Ca(2+)-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation. Cell Res., 23, 2013
3JYF	The crystal structure of a 2,3-cyclic nucleotide 2-phosphodiesterase/3-nucleotidase bifunctional periplasmic precursor protein from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 分子名称: 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase bifunctional periplasmic protein, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... 著者 Fan, Y, Volkart, L, Cobb, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2009-09-21 公開日 2009-09-29 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 The crystal structure of a 2,3-cyclic nucleotide 2-phosphodiesterase/3-nucleotidase bifunctional periplasmic precursor protein from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 To be Published
6YE2	Human Ecto-5'-nucleotidase (CD73) in complex with the AMPCP derivative A1202 (compound 4a in publication) in the closed form (crystal form IV) 分子名称: 5'-nucleotidase, CALCIUM ION, ZINC ION, ... 著者 Scaletti, E, Strater, N. 登録日 2020-03-23 公開日 2021-01-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J.Med.Chem., 64, 2021
7JV8	Human CD73 (ecto 5'-nucleotidase) in complex with compound 35 分子名称: 5'-nucleotidase, 6-chloro-N-cyclopentyl-1-{5-O-[(2R)-1-hydroxy-3-methoxy-2-phosphonopropan-2-yl]-beta-D-ribofuranosyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, ... 著者 Gibbons, P, Du, X. 登録日 2020-08-20 公開日 2020-09-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production. J.Med.Chem., 63, 2020
1TCO	TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS) 分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, FE (III) ION, ... 著者 Griffith, J.P, Kim, J.L, Kim, E.E, Sintchak, M.D, Thomson, J.A, Fitzgibbon, M.J, Fleming, M.A, Caron, P.R, Hsiao, K, Navia, M.A. 登録日 1996-08-21 公開日 1997-02-12 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell(Cambridge,Mass.), 82, 1995
4FBQ	Crystal structure of a covalently fused Nbs1-Mre11 complex with two manganese ions per active site 分子名称: DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN, MANGANESE (II) ION 著者 Schiller, C.B, Lammens, K, Hopfner, K.P. 登録日 2012-05-23 公開日 2012-06-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling. Nat.Struct.Mol.Biol., 19, 2012
1XZW	Sweet potato purple acid phosphatase/phosphate complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, ... 著者 Schenk, G, Carrington, L.E, Gahan, L.R, Hamilton, S.E, de Jersey, J, Guddat, L.W. 登録日 2004-11-12 公開日 2004-12-14 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase Proc.Natl.Acad.Sci.USA, 102, 2005
1S3M	Structural and Functional Characterization of a Novel Archaeal Phosphodiesterase 分子名称: Hypothetical protein MJ0936, NICKEL (II) ION 著者 Chen, S, Busso, D, Yakunin, A.F, Kuznetsova, E, Proudfoot, M, Jancrick, J, Kim, R, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) 登録日 2004-01-13 公開日 2004-08-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii J.Biol.Chem., 279, 2004
1S3N	Structural and Functional Characterization of a Novel Archaeal Phosphodiesterase 分子名称: Hypothetical protein MJ0936, MANGANESE (II) ION 著者 Chen, S, Busso, D, Yakunin, A.F, Kuznetsova, E, Proudfoot, M, Jancrick, J, Kim, R, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) 登録日 2004-01-13 公開日 2004-08-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii J.Biol.Chem., 279, 2004
8DWK	Inhibitor-3:PP1 reconstituted complex 分子名称: E3 ubiquitin-protein ligase PPP1R11, MANGANESE (II) ION, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 著者 Choy, M.S, Srivastava, G, Page, R, Peti, W. 登録日 2022-08-01 公開日 2023-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction. Nat Commun, 14, 2023
5IHE	D-family DNA polymerase - DP1 subunit (3'-5' proof-reading exonuclease) 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ACETATE ION, ... 著者 Sauguet, L, Raia, P, De Larue, M. 登録日 2016-02-29 公開日 2016-08-31 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography. Nat Commun, 7, 2016
2O8G	Rat pp1c gamma complexed with mouse inhibitor-2 分子名称: MANGANESE (II) ION, Protein phosphatase inhibitor 2, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit 著者 Hurley, T.D. 登録日 2006-12-12 公開日 2007-07-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J.Biol.Chem., 282, 2007
6TZ7	Crystal Structure of Aspergillus fumigatus Calcineurin A, Calcineurin B, FKBP12 and FK506 (Tacrolimus) 分子名称: 1,2-ETHANEDIOL, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, ... 著者 Fox III, D, Horanyi, P.S. 登録日 2019-08-10 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nat Commun, 10, 2019
5I85	aSMase with zinc and phosphocholine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOCHOLINE, ... 著者 Zhou, Y.F, Wei, R.R. 登録日 2016-02-18 公開日 2016-09-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease. Nat Commun, 7, 2016
6UNC	The crystal structure of Phosphopantetheinyl Hydrolase (PptH) from Mycobacterium tuberculosis 分子名称: FE (III) ION, MANGANESE (II) ION, Metallophos domain-containing protein 著者 Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2019-10-11 公開日 2020-04-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis. Protein Sci., 29, 2020
6TWF	Human CD73 (ecto 5'-nucleotidase) in complex with PSB12604 (an AOPCP derivative, compound 21 in publication) in the closed state 分子名称: 5'-nucleotidase, CALCIUM ION, ZINC ION, ... 著者 Pippel, J, Strater, N. 登録日 2020-01-13 公開日 2020-02-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes. J.Med.Chem., 63, 2020

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