4O43

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

Summary for 4O43

Related4NZV 4O24 4O4K 4O5G
DescriptorExonuclease, putative, MANGANESE (II) ION, (5~{E})-3-[(2~{R})-butan-2-yl]-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, ... (4 entities in total)
Functional Keywordsdna repair dna double-strand break repair thermophilic mre11 nuclease, dna repair dna double-strand break repair, dna binding protein-inhibitor complex, dna binding protein/inhibitor
Biological sourceThermotoga maritima
Total number of polymer chains2
Total molecular weight77956.99
Authors
Primary citation
Shibata, A.,Moiani, D.,Arvai, A.S.,Perry, J.,Harding, S.M.,Genois, M.M.,Maity, R.,van Rossum-Fikkert, S.,Kertokalio, A.,Romoli, F.,Ismail, A.,Ismalaj, E.,Petricci, E.,Neale, M.J.,Bristow, R.G.,Masson, J.Y.,Wyman, C.,Jeggo, P.A.,Tainer, J.A.
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.
Mol.Cell, 53:7-18, 2014
PubMed: 24316220 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2013.11.003
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2565 0.3% 2.0% 6.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
168889
PDB entries from 2020-09-16