4O43
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN A 401 |
| Chain | Residue |
| A | ASP58 |
| A | HIS180 |
| A | HIS216 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 402 |
| Chain | Residue |
| A | ASP14 |
| A | HIS16 |
| A | HIS216 |
| A | HIS218 |
| A | HOH529 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 2PW A 403 |
| Chain | Residue |
| A | PRO66 |
| A | LEU75 |
| A | LEU99 |
| A | PHE115 |
| B | PHE102 |
| A | LEU60 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 2PW A 404 |
| Chain | Residue |
| A | PHE102 |
| B | PRO66 |
| B | LEU75 |
| B | HIS94 |
| B | LEU99 |
| B | PHE115 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN B 401 |
| Chain | Residue |
| B | ASP58 |
| B | HIS180 |
| B | HIS216 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN B 402 |
| Chain | Residue |
| B | ASP14 |
| B | HIS16 |
| B | HIS216 |
| B | HIS218 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q8U1N9","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_02044","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3THN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O24","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O5G","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3THN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3THO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O24","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4O4K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21937514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24316220","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4NZV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
