4O43

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Exonuclease, putative	polymer	336	38575.2	2	UniProt (Q9X1X0) Pfam (PF00149) In PDB	Thermotoga maritima
2	A, B	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
3	A	(5~{E})-3-[(2~{R})-butan-2-yl]-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one	non-polymer		293.4	2	Chemie (2PW)
4		water	water		18.0	122	Chemie (HOH)

Sequence modifications

A, B: -11 - 324 (UniProt: Q9X1X0)

PDB	External Database	Details
Gly -10	-	expression tag
Ser -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Ile -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Val 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77150.4
Non-Polymers*	Number of molecules	6
	Total formula weight	806.6
All*	Total formula weight	77957.0

*Water molecules are not included.