4O24

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

Summary for 4O24

• Entry DOI: 10.2210/pdb4o24/pdb
• Related: 4NZV 4O43 4O4K 4O5G
• Descriptor: Exonuclease, putative, (5~{Z})-5-[(4-hydroxyphenyl)methylidene]-3-(2-methylpropyl)-2-sulfanylidene-1,3-thiazolidin-4-one, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: dna repair dna double-strand break repair thermophilic mre11 nuclease, dna repair dna double-strand break repair, dna binding protein-inhibitor complex, dna binding protein/inhibitor
• Biological source: Thermotoga maritima
• Total number of polymer chains: 2
• Total formula weight: 77694.60

Authors

Shibata, A.,Moiani, D.,Arvai, A.S.,Perry, J.,Harding, S.M.,Genois, M.,Maity, R.,Rossum-Fikkert, S.,Kertokalio, A.,Romoli, F.,Ismail, A.,Ismalaj, E.,Petricci, E.,Neale, M.J.,Bristow, R.G.,Masson, J.,Wyman, C.,Jeggo, P.A.,Tainer, J.A. (deposition date: 2013-12-16, release date: 2014-01-15, Last modification date: 2023-09-20)

• Primary citation: Shibata, A.,Moiani, D.,Arvai, A.S.,Perry, J.,Harding, S.M.,Genois, M.M.,Maity, R.,van Rossum-Fikkert, S.,Kertokalio, A.,Romoli, F.,Ismail, A.,Ismalaj, E.,Petricci, E.,Neale, M.J.,Bristow, R.G.,Masson, J.Y.,Wyman, C.,Jeggo, P.A.,Tainer, J.A.; DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.; Mol.Cell, 53:7-18, 2014; PubMed: 24316220; DOI: 10.1016/j.molcel.2013.11.003

Experimental method

X-RAY DIFFRACTION (2.3 Å)